Immunology Antibodies 2
Anti-IL-1A Antibody (CAB2170)
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- SKU:
- CAB2170
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | IL1A Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB2170 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 112-271 of human IL1A (NP_000566.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NCI-H460, SKOV3, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 112-271 of human IL1A (NP_000566.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RSAP FSFL SNVK YNFM RIIK YEFI LNDA LNQS IIRA NDQY LTAA ALHN LDEA VKFD MGAY KSSK DDAK ITVI LRIS KTQL YVTA QDED QPVL LKEM PEIP KTIT GSET NLLF FWET HGTK NYFT SVAH PNLF IATK QDYW VCLA GGPP SITD FQIL ENQA |
| Gene ID: | 3552 |
| Uniprot: | P01583 |
| Cellular Location: | Secreted |
| Calculated MW: | 30kDa |
| Observed MW: | 36kDa |
| Synonyms: | IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 |
| Background: | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. |
| UniProt Protein Function: | IL1A: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Belongs to the IL-1 family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytokine Chromosomal Location of Human Ortholog: 2q14 Cellular Component: extracellular space; extracellular region; cytosol Molecular Function:protein binding; copper ion binding; interleukin-1 receptor binding; cytokine activity Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of mitosis; apoptosis; positive regulation of interleukin-2 biosynthetic process; cytokine and chemokine mediated signaling pathway; germ cell programmed cell death; positive regulation of JNK cascade; fever; negative regulation of cell proliferation; cell proliferation; connective tissue replacement during inflammatory response; positive regulation of angiogenesis; response to copper ion; positive regulation of transcription from RNA polymerase II promoter; immune response; inflammatory response; positive regulation of cytokine secretion |
| NCBI Summary: | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P01583 |
| NCBI GenInfo Identifier: | 124297 |
| NCBI Gene ID: | 3552 |
| NCBI Accession: | P01583.1 |
| UniProt Secondary Accession: | P01583,Q53QF9, Q7RU02, |
| UniProt Related Accession: | P01583 |
| Molecular Weight: | 30,607 Da |
| NCBI Full Name: | Interleukin-1 alpha |
| NCBI Synonym Full Names: | interleukin 1, alpha |
| NCBI Official Symbol: | IL1A |
| NCBI Official Synonym Symbols: | IL1; IL-1A; IL1F1; IL1-ALPHA |
| NCBI Protein Information: | interleukin-1 alpha; IL-1 alpha; hematopoietin-1; preinterleukin 1 alpha; pro-interleukin-1-alpha |
| UniProt Protein Name: | Interleukin-1 alpha |
| UniProt Synonym Protein Names: | Hematopoietin-1 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL1A |
| UniProt Entry Name: | IL1A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL1A antibody (CAB2170) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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