Immunology Antibodies 2
Anti-IL-18R1 Antibody (CAB2706)
(No reviews yet)
Write a Review
- SKU:
- CAB2706
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | IL18R1 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB2706 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB, IF, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-320 of human IL18R1 (NP_003846.1). |
| Application: | WB, IF, IHC |
| Recommended Dilution: | WB 1:500 - 1:1000 IF 1:50 - 1:200 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NCI-H460 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-320 of human IL18R1 (NP_003846.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AESC TSRP HITV VEGE PFYL KHCS CSLA HEIE TTTK SWYK SSGS QEHV ELNP RSSS RIAL HDCV LEFW PVEL NDTG SYFF QMKN YTQK WKLN VIRR NKHS CFTE RQVT SKIV EVKK FFQI TCEN SYYQ TLVN STSL YKNC KKLL LENN KNPT IKKN AEFE DQGY YSCV HFLH HNGK LFNI TKTF NITI VEDR SNIV PVLL GPKL NHVA VELG KNVR LNCS ALLN EEDV IYWM FGEE NGSD PNIH EEKE MRIM TPEG KWHA SKVL RIEN IGES NLNV LYNC TVAS TGGT DTKS FILV RKAD MA |
| Gene ID: | 8809 |
| Uniprot: | Q13478 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 62kDa |
| Observed MW: | 75kDa |
| Synonyms: | IL18R1, CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP |
| Background: | The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | IL18R1: Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B. Belongs to the interleukin-1 receptor family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 2q12 Cellular Component: plasma membrane; integral to membrane Molecular Function:protein binding; receptor activity; interleukin-1 receptor activity; interleukin-18 receptor activity Biological Process: positive regulation of interferon-gamma production; T-helper 1 cell differentiation; natural killer cell activation; immune response; positive regulation of NF-kappaB import into nucleus; signal transduction |
| NCBI Summary: | The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q13478 |
| NCBI GenInfo Identifier: | 26395370 |
| NCBI Gene ID: | 8809 |
| NCBI Accession: | Q13478.1 |
| UniProt Secondary Accession: | Q13478,Q52LC9, B2R9Y5, |
| UniProt Related Accession: | Q13478 |
| Molecular Weight: | 62,304 Da |
| NCBI Full Name: | Interleukin-18 receptor 1 |
| NCBI Synonym Full Names: | interleukin 18 receptor 1 |
| NCBI Official Symbol: | IL18R1 |
| NCBI Official Synonym Symbols: | CD218a; IL18RA; IL1RRP; CDw218a; IL-1Rrp |
| NCBI Protein Information: | interleukin-18 receptor 1; IL-18R1; IL1R-rp; IL-18R-1; IL18Ralpha2; cytokine receptor; IL1 receptor-related protein; CD218 antigen-like family member A |
| UniProt Protein Name: | Interleukin-18 receptor 1 |
| UniProt Synonym Protein Names: | CD218 antigen-like family member A; CDw218a; IL1 receptor-related protein; IL-1Rrp; IL1R-rp; CD_antigen: CD218a |
| Protein Family: | Interleukin-18 receptor |
| UniProt Gene Name: | IL18R1 |
| UniProt Entry Name: | IL18R_HUMAN |
 | Western blot analysis of extracts of NCI-H460 cells, using IL18R1 antibody (CAB2706) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
View AllClose
Related Products
Human IL-18R1 / IL-18 receptor 1 ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
