Cell Biology Antibodies 3
Anti-IL-13 Antibody (CAB12453)
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- SKU:
- CAB12453
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | IL13 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB12453 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-146 of human IL13 (NP_002179.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | MCF7, HL-60, B cells |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-146 of human IL13 (NP_002179.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LTCL GGFA SPGP VPPS TALR ELIE ELVN ITQN QKAP LCNG SMVW SINL TAGM YCAA LESL INVS GCSA IEKT QRML SGFC PHKV SAGQ FSSL HVRD TKIE VAQF VKDL LLHL KKLF REGQ FN |
| Gene ID: | 3596 |
| Uniprot: | P35225 |
| Cellular Location: | Secreted |
| Calculated MW: | 15kDa |
| Observed MW: | 13kDa |
| Synonyms: | IL13, IL-13, P600 |
| Background: | This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. |
| UniProt Protein Function: | IL13: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH). Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Belongs to the IL-4/IL-13 family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 5q31 Cellular Component: extracellular region; extracellular space Molecular Function:interleukin-13 receptor binding; protein binding Biological Process: cell motility; cell-cell signaling; positive regulation of B cell proliferation; positive regulation of immunoglobulin production; positive regulation of macrophage activation; positive regulation of mast cell degranulation Disease: Allergic Rhinitis; Asthma, Susceptibility To |
| NCBI Summary: | This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P35225 |
| NCBI GenInfo Identifier: | 239938644 |
| NCBI Gene ID: | 3596 |
| NCBI Accession: | P35225.2 |
| UniProt Secondary Accession: | P35225,O43644, Q4VB52, Q9UDC7, |
| UniProt Related Accession: | P35225 |
| Molecular Weight: | 15,816 Da |
| NCBI Full Name: | Interleukin-13 |
| NCBI Synonym Full Names: | interleukin 13 |
| NCBI Official Symbol: | IL13 |
| NCBI Official Synonym Symbols: | P600; IL-13 |
| NCBI Protein Information: | interleukin-13 |
| UniProt Protein Name: | Interleukin-13 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL13 |
| UniProt Entry Name: | IL13_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL13 antibody (CAB12453) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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