Immunology Antibodies 3
Anti-IKKBeta Antibody (CAB19606)
- SKU:
- CAB19606
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
Antibody Name: | Anti-IKKBeta Antibody |
Antibody SKU: | CAB19606 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | A synthesized peptide derived from human IKKBeta. |
Application: | WB IHC |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
Reactivity: | Human |
Positive Samples: | Jurkat, HepG2, HeLa, A-549 |
Immunogen: | A synthesized peptide derived from human IKKBeta. |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 3551 |
Uniprot: | O14920 |
Cellular Location: | |
Calculated MW: | 87kDa |
Observed MW: | 87KDa |
Synonyms: | IKBKB, IKK-beta, IKK2, IKKB, IMD15, NFKBIKB, IKK beta |
Background: | The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011] |
UniProt Protein Function: | IKKB: a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Preferentially found as a heterodimer with IKK-alpha but also as an homodimer. |
UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.11.10; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; IKK family Chromosomal Location of Human Ortholog: 8p11.2 Cellular Component: internal side of plasma membrane; cytoplasm; IkappaB kinase complex; cytosol; nucleus; lipid raft Molecular Function:protein serine/threonine kinase activity; protein binding; protein homodimerization activity; IkappaB kinase activity; protein heterodimerization activity; protein kinase binding; ATP binding; protein kinase activity Biological Process: I-kappaB kinase/NF-kappaB cascade; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; B cell homeostasis; positive regulation of interferon type I production; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; response to virus; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; serine phosphorylation of STAT protein; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; I-kappaB phosphorylation; negative regulation of apoptosis Disease: Immunodeficiency 15 |
NCBI Summary: | The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011] |
UniProt Code: | O14920 |
NCBI GenInfo Identifier: | 14285497 |
NCBI Gene ID: | 3551 |
NCBI Accession: | O14920.1 |
UniProt Secondary Accession: | O14920,O75327, B4DZ30, B4E0U4, |
UniProt Related Accession: | O14920 |
Molecular Weight: | 86,564 Da |
NCBI Full Name: | Inhibitor of nuclear factor kappa-B kinase subunit beta |
NCBI Synonym Full Names: | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta |
NCBI Official Symbol: | IKBKB |
NCBI Official Synonym Symbols: | IKK2; IKKB; IMD15; NFKBIKB; IKK-beta |
NCBI Protein Information: | inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-B; I-kappa-B kinase 2; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta |
UniProt Protein Name: | Inhibitor of nuclear factor kappa-B kinase subunit beta |
UniProt Synonym Protein Names: | I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta |
UniProt Gene Name: | IKBKB |
UniProt Entry Name: | IKKB_HUMAN |