| UniProt Protein Function: | IFI16: a nuclear protein that may function as a transcriptional repressor. Strongly induced by gamma interferon and, to a lesser extent, by alpha interferon. Binds double-stranded DNA and cell cycle regulatory factors including p53 and Rb. Loss of IFI16 activates p53 checkpoint through NBS1-DNAPK pathway. Inhibits cell growth in the Ras/Raf signaling pathway. May be involved in the senescence of prostate epithelial cells. Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prostate, ovary and breast. Four alternatively spliced isoforms have been described. Isoforms-1, -2 and -3 can homo- and hetero-dimerize. |
| UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 1q22 Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; nuclear speck; cytosol; nucleus Molecular Function:identical protein binding; protein binding; double-stranded DNA binding; transcription factor binding Biological Process: positive regulation of cytokine production; transcription, DNA-dependent; monocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic; negative regulation of DNA binding; cellular response to glucose starvation; positive regulation of interleukin-1 beta production; cell proliferation; negative regulation of viral genome replication; negative regulation of innate immune response; positive regulation of interferon type I production; autophagy; innate immune response; hemopoiesis; positive regulation of transcription from RNA polymerase II promoter; myeloid cell differentiation; regulation of autophagy; negative regulation of transcription, DNA-dependent; inflammatory response; defense response to virus; activation of innate immune response; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis |
| NCBI Summary: | This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011] |
| UniProt Code: | Q16666 |
| NCBI GenInfo Identifier: | 118572657 |
| NCBI Gene ID: | 3428 |
| NCBI Accession: | Q16666.3 |
| UniProt Secondary Accession: | Q16666,Q59GX0, Q5T3W7, Q5T3W8, Q5T3X0, Q5T3X1, Q5T3X2 Q8N9E5, Q8NEQ7, Q96AJ5, B4DJT8, H3BLV7, |
| UniProt Related Accession: | Q16666 |
| Molecular Weight: | 785 |
| NCBI Full Name: | Gamma-interferon-inducible protein 16 |
| NCBI Synonym Full Names: | interferon, gamma-inducible protein 16 |
| NCBI Official Symbol: | IFI16 |
| NCBI Official Synonym Symbols: | PYHIN2; IFNGIP1 |
| NCBI Protein Information: | gamma-interferon-inducible protein 16; interferon-gamma induced protein IFI 16; interferon-inducible myeloid differentiation transcriptional activator |
| UniProt Protein Name: | Gamma-interferon-inducible protein 16 |
| UniProt Synonym Protein Names: | Interferon-inducible myeloid differentiation transcriptional activator |
| Protein Family: | Gamma-interferon-inducible protein |
| UniProt Gene Name: | IFI16 |
| UniProt Entry Name: | IF16_HUMAN |
