Cell Biology Antibodies 9
Anti-ICAM3 Antibody (CAB3923)
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- SKU:
- CAB3923
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ICAM3 Antibody |
| Antibody SKU: | CAB3923 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-490 of human ICAM3 (NP_002153.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | LO2, A-549, SW480 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-490 of human ICAM3 (NP_002153.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HGDT LTAT ATAT ARAD QEGA REIV CNVT LGGE RREA RENL TVFS FLGP IVNL SEPT AHEG STVT VSCM AGAR VQVT LDGV PAAA PGQP AQLQ LNAT ESDD GRSF FCSA TLEV DGEF LHRN SSVQ LRVL YGPK IDRA TCPQ HLKW KDKT RHVL QCQA RGNP YPEL RCLK EGSS REVP VGIP FFVN VTHN GTYQ CQAS SSRG KYTL VVVM DIEA GSSH FVPV F |
| Gene ID: | 3385 |
| Uniprot: | P32942 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 59kDa |
| Observed MW: | 150kDa |
| Synonyms: | ICAM3, CD50, CDW50, ICAM-R |
| Background: | The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | ICAM3: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. Belongs to the immunoglobulin superfamily. ICAM family. |
| UniProt Protein Details: | Protein type:Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:integrin binding; protein binding; receptor binding Biological Process: cell adhesion; extracellular matrix organization and biogenesis; regulation of immune response; stimulatory C-type lectin receptor signaling pathway |
| NCBI Summary: | The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016] |
| UniProt Code: | P32942 |
| NCBI GenInfo Identifier: | 206729872 |
| NCBI Gene ID: | 3385 |
| NCBI Accession: | P32942.2 |
| UniProt Secondary Accession: | P32942,Q6PD68, |
| UniProt Related Accession: | P32942 |
| Molecular Weight: | 59,541 Da |
| NCBI Full Name: | Intercellular adhesion molecule 3 |
| NCBI Synonym Full Names: | intercellular adhesion molecule 3 |
| NCBI Official Symbol: | ICAM3 |
| NCBI Official Synonym Symbols: | CD50; CDW50; ICAM-R |
| NCBI Protein Information: | intercellular adhesion molecule 3 |
| UniProt Protein Name: | Intercellular adhesion molecule 3 |
| UniProt Synonym Protein Names: | CDw50; ICAM-R; CD_antigen: CD50 |
| UniProt Gene Name: | ICAM3 |
 | Western blot analysis of extracts of various cell lines, using ICAM3 antibody (CAB3923) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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