Cell Biology Antibodies 8

Anti-IAPP Antibody (CAB2816)

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SKU:
CAB2816
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-IAPP Antibody
Antibody SKU:CAB2816
Antibody Size:20uL, 50uL, 100uL
Application:IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human IAPP
Application:IHC IF
Recommended Dilution:IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:A synthetic peptide of human IAPP
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3375
Uniprot:P10997
Cellular Location:Secreted
Calculated MW:9kDa
Observed MW:Refer to figures
Synonyms:IAPP, DAP, IAP
Background:This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity.
UniProt Protein Function:IAPP: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Belongs to the calcitonin family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12p12.1

Cellular Component: extracellular space; cell soma; extracellular region

Molecular Function:identical protein binding; hormone activity; receptor binding

Biological Process: negative regulation of cell differentiation; cell-cell signaling; eating behavior; apoptosis; sensory perception of pain; negative regulation of bone resorption; signal transduction; endocrine pancreas development

NCBI Summary:The protein encoded by this gene is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity. [provided by RefSeq, Sep 2014]
UniProt Code:P10997
NCBI GenInfo Identifier:124006
NCBI Gene ID:3375
NCBI Accession:P10997.1
UniProt Secondary Accession:P10997,Q0ZD87, Q14598,
UniProt Related Accession:P10997
Molecular Weight:89
NCBI Full Name:Islet amyloid polypeptide
NCBI Synonym Full Names:islet amyloid polypeptide
NCBI Official Symbol:IAPP  
NCBI Official Synonym Symbols:DAP; IAP  
NCBI Protein Information:islet amyloid polypeptide; amylin; insulinoma amyloid peptide; diabetes-associated peptide; Islet amyloid polypeptide (diabetes-associated peptide; amylin)
UniProt Protein Name:Islet amyloid polypeptide
UniProt Synonym Protein Names:Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide
Protein Family:Islet amyloid polypeptide
UniProt Gene Name:IAPP  
UniProt Entry Name:IAPP_HUMAN
Anti-IAPP Antibody (CAB2816)Immunohistochemistry of paraffin-embedded Rat pancreas using IAPP Rabbit pAb (CAB2816) at dilution of 1:100 (40x lens).
Anti-IAPP Antibody (CAB2816)Immunohistochemistry of paraffin-embedded Mouse pancreas using IAPP Rabbit pAb (CAB2816) at dilution of 1:100 (40x lens).
Anti-IAPP Antibody (CAB2816)Immunofluorescence analysis of rat pancreas using IAPP antibody (CAB2816) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-IAPP Antibody (CAB2816)Immunofluorescence analysis of mouse pancreas using IAPP antibody (CAB2816) at dilution of 1:100. Blue: DAPI for nuclear staining.
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