Metabolism Antibodies 1

Anti-HYOU1 Antibody (CAB12313)

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SKU:
CAB12313
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-HYOU1 Antibody
Antibody SKU:CAB12313
Antibody Size:20uL, 50uL, 100uL
Application:IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human HYOU1 (NP_001124463.1).
Application:IF
Recommended Dilution:IF 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human HYOU1 (NP_001124463.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MADK VRRQ RPRR RVCW ALVA VLLA DLLA LSDT LAVM SVDL GSES MKVA IVKP GVPM EIVL NKES RRKT PVIV TLKE NERF FGDS AASM AIKN PKAT LRYF QHLL GKQA DNPH VALY QARF PEHE LTFD PQRQ TVHF QISS
Gene ID:10525
Uniprot:Q9Y4L1
Cellular Location:Endoplasmic reticulum lumen
Calculated MW:62kDa/111kDa
Observed MW:
Synonyms:HYOU1, GRP-170, Grp170, HSP12A, ORP-150, ORP150
Background:The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:HYOU1: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. Belongs to the heat shock protein 70 family.
UniProt Protein Details:

Protein type:Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 11q23.1-q23.3

Cellular Component: endoplasmic reticulum lumen; extracellular region; focal adhesion; membrane; smooth endoplasmic reticulum

Molecular Function:chaperone binding

Biological Process: ER to Golgi vesicle-mediated transport; receptor-mediated endocytosis

NCBI Summary:The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
UniProt Code:Q9Y4L1
NCBI GenInfo Identifier:10720185
NCBI Gene ID:10525
NCBI Accession:Q9Y4L1.1
UniProt Secondary Accession:Q9Y4L1,Q2I204, Q53H25, A8C1Z0, B7Z909,
UniProt Related Accession:Q9Y4L1
Molecular Weight:62,757 Da
NCBI Full Name:Hypoxia up-regulated protein 1
NCBI Synonym Full Names:hypoxia up-regulated 1
NCBI Official Symbol:HYOU1  
NCBI Official Synonym Symbols:Grp170; HSP12A; ORP150; GRP-170; ORP-150  
NCBI Protein Information:hypoxia up-regulated protein 1
UniProt Protein Name:Hypoxia up-regulated protein 1
UniProt Synonym Protein Names:150 kDa oxygen-regulated protein; ORP-150; 170 kDa glucose-regulated protein; GRP-170
Protein Family:Hypoxia up-regulated protein
UniProt Gene Name:HYOU1  
UniProt Entry Name:HYOU1_HUMAN
Anti-HYOU1 Antibody (CAB12313)Immunofluorescence analysis of A549 cells using HYOU1 antibody (CAB12313). Blue: DAPI for nuclear staining.
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