Developmental Biology
Anti-HYAL3 Antibody (CAB14075)
- SKU:
- CAB14075
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-HYAL3 Antibody |
| Antibody SKU: | CAB14075 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 198-417 of human HYAL3 (NP_003540.2). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 198-417 of human HYAL3 (NP_003540.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GFYH YPAC GNGW HSMA SNYT GRCH AATL ARNT QLHW LWAA SSAL FPSI YLPP RLPP AHHQ AFVR HRLE EAFR VALV GHRH PLPV LAYV RLTH RRSG RFLS QDDL VQSI GVSA ALGA AGVV LWGD LSLS SSEE ECWH LHDY LVDT LGPY VINV TRAA MACS HQRC HGHG RCAR RDPG QMEA FLHL WPDG SLGD WKSF SCHC YWGW AGPT CQEP RPGP KEAV |
| Gene ID: | 8372 |
| Uniprot: | O43820 |
| Cellular Location: | Lysosome, Secreted |
| Calculated MW: | 15kDa/18kDa/43kDa/46kDa |
| Observed MW: |
| Synonyms: | HYAL3, HYAL-3, LUCA-3, LUCA3 |
| Background: | This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. |
| UniProt Protein Function: | HYAL3: a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011] |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Hydrolase; EC 3.2.1.35; Secreted Chromosomal Location of Human Ortholog: 3p21.3 Cellular Component: lysosome; extracellular region; cytoplasmic vesicle Molecular Function:viral receptor activity; hyaluronoglucuronidase activity; hyalurononglucosaminidase activity Biological Process: response to antibiotic; cartilage development; response to virus; carbohydrate metabolic process; inflammatory response; hyaluronan catabolic process |
| NCBI Summary: | This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011] |
| UniProt Code: | O43820 |
| NCBI GenInfo Identifier: | 74739561 |
| NCBI Gene ID: | 8372 |
| NCBI Accession: | O43820.1 |
| UniProt Secondary Accession: | O43820,O60540, Q8NFK2, Q8NFK3, Q8NFK4, Q96E56, Q9BRW9 |
| UniProt Related Accession: | O43820 |
| Molecular Weight: | 417 |
| NCBI Full Name: | Hyaluronidase-3 |
| NCBI Synonym Full Names: | hyaluronoglucosaminidase 3 |
| NCBI Official Symbol: | HYAL3 |
| NCBI Official Synonym Symbols: | LUCA3; HYAL-3; LUCA-3 |
| NCBI Protein Information: | hyaluronidase-3; lung carcinoma protein 3 |
| UniProt Protein Name: | Hyaluronidase-3 |
| UniProt Synonym Protein Names: | Hyaluronoglucosaminidase-3; Lung carcinoma protein 3; LuCa-3 |
| UniProt Gene Name: | HYAL3 |
| UniProt Entry Name: | HYAL3_HUMAN |
 | Immunofluorescence analysis of U2OS cells using HYAL3 antibody (CAB14075). Blue: DAPI for nuclear staining. |
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