Anti-Human TIGIT [4E1.2] In Vivo Antibody - Low Endotoxin
![Anti-Human TIGIT [4E1.2] In Vivo Antibody - Low Endotoxin](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/78967/84149/anti-human-tigit-4e1.2-in-vivo-antibody-low-endotoxin__05822__49848.1706545518.jpg?c=1 "Anti-Human TIGIT [4E1.2] In Vivo Antibody - Low Endotoxin")
- SKU:
- IVMB0267
- Product Type:
- In Vivo Monoclonal Antibody
- Clone:
- 4E1.2
- Protein:
- TIGIT
- Isotype:
- IgG3 k
- Reactivity:
- Human
- Synonyms:
- VSIG9
- Synonyms:
- Vstm3
- Synonyms:
- WUCAM
- Research Area:
- Immunology
- Endotoxin Level:
- Low Endotoxin
- Host Species:
- Mouse
- Applications:
- Blocking
- Applications:
- FC
- Applications:
- In Vivo
![Anti-Human TIGIT [4E1.2] In Vivo Antibody - Low Endotoxin](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/78967/84149/anti-human-tigit-4e1.2-in-vivo-antibody-low-endotoxin__05822__49848.1706545518.jpg?c=1&imbypass=on "Anti-Human TIGIT [4E1.2] In Vivo Antibody - Low Endotoxin")
Description
| Product Name: | Anti-Human TIGIT (Clone 4E1.2) In Vivo Antibody - Low Endotoxin |
| Product Code: | IVMB0267 |
| Size: | 1 mg, 5 mg, 25 mg, 50 mg, 100 mg |
| Clone: | 4E1.2 |
| Protein: | TIGIT |
| Product Type: | Monoclonal Antibody |
| Synonyms: | VSIG9, Vstm3, WUCAM |
| Isotype: | IgG3 k |
| Reactivity: | Human |
| Applications: | B, FC, In Vivo |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 200 mM arginine, 50 mM histidine, and 100 mM NaCl at a pH of 6.4 – 6.6, with no carrier protein, potassium or preservatives added Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration. |
| Endotoxin Level: | < 1.0 EU/mg as determined by the LAL method |
| Purity: | ≥95% monomer by analytical SEC ⋅ >95% by SDS Page |
| Product Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Applications: | B, FC, In Vivo |
| Reactivity: | Human |
| Host Species: | Mouse |
| Specificity: | Clone 4E1.2 activity is directed against human TIGIT (WUCAM). |
| Antigen Distribution: | TIGIT is expressed on activated CXCR5+CD4+ T cells in peripheral blood, variably on CD8+ T cells and CD56+CD3- NK cells, and constitutively in tonsils on some CD3+CD8int T cells as well as the CXCR5high/ICOShigh subset of CD4+ T cells that contains fully differentiated TFH cells. |
| Concentration: | ≥ 5.0 mg/ml |
| Endotoxin Level: | < 1.0 EU/mg as determined by the LAL method |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 200 mM arginine, 50 mM histidine, and 100 mM NaCl at a pH of 6.4 – 6.6, with no carrier protein, potassium or preservatives added Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration. |
| Purity: | ≥95% monomer by analytical SEC ⋅ >95% by SDS Page |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -70°C. Avoid Repeated Freeze Thaw Cycles. Note: This antibody is prone to precipitation at 2-8°C resulting in a slight opaque white liquid. At room temperature liquid is clear and colorless. |
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