Anti-HSP47 Antibody [1C4-1A6]

HSP47 Antibody [1C4-1A6]

HSP47 Antibody [1C4-1A6] is a mouse monoclonal antibody directed against HSP47, offered by Assay Genie for research applications. Reported applications include WB and ICC/IF. Reported reactivity: Human. Supplied as IgG1 Kappa, purified by Protein G.

HSP47, also known as SERPINH1, is a unique member of the serine protease inhibitor (serpin) superfamily that functions as a collagen-specific molecular chaperone. Localized in the endoplasmic reticulum, HSP47 plays a critical role in the intracellular folding, assembly, and secretion of procollagens—particularly type I collagen, a key structural component in tissue repair and remodeling. Unlike other heat shock proteins, HSP47 binds a single substrate: collagen. This specificity makes it a promising biomarker and therapeutic target in fibrotic diseases, where its expression is markedly elevated around fibrotic lesions. Recent studies suggest that modulating HSP47 activity could support cell-based therapies aimed at halting or reversing fibrosis progression. In the context of neuroscience, HSP47 is gaining attention for its role in post-injury tissue remodeling. Type I collagen is essential for scar formation and structural integrity following events such as myocardial infarction or central nervous system injury. HSP47 facilitates the proper positioning of collagen-producing cells and the assembly of collagen fibrils—processes that are also relevant in neurodegenerative conditions involving extracellular matrix dysregulation. Given its substrate specificity and stress-inducible nature, HSP47 represents a novel intersection between fibrosis, wound healing, and neurodegeneration, with potential as a universal marker and therapeutic target in regenerative medicine. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 200 µg. For research use only; not for diagnostic or therapeutic procedures.