Cell Biology Antibodies 1
Anti-HPCAL1 Antibody (CAB10019)
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- SKU:
- CAB10019
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-HPCAL1 Antibody |
| Antibody SKU: | CAB10019 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-193 of human HPCAL1 (NP_002140.2). |
| Application: | WB IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IP 1:20 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, HepG2, HT-1080, NCI-H460, HeLa, Mouse brain, Mouse liver, Mouse kidney, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-193 of human HPCAL1 (NP_002140.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGKQ NSKL RPEV LQDL RENT EFTD HELQ EWYK GFLK DCPT GHLT VDEF KKIY ANFF PYGD ASKF AEHV FRTF DTNG DGTI DFRE FIIA LSVT SRGK LEQK LKWA FSMY DLDG NGYI SRSE MLEI VQAI YKMV SSVM KMPE DEST PEKR TDKI FRQM DTNN DGKL SLEE FIRG AKSD PSIV RLLQ CDPS SASQ F |
| Gene ID: | 3241 |
| Uniprot: | P37235 |
| Cellular Location: | Lipid-anchor, Membrane |
| Calculated MW: | 22kDa |
| Observed MW: | 17kDa |
| Synonyms: | HPCAL1, BDR1, HLP2, VILIP-3 |
| Background: | The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | HPCAL1: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Belongs to the recoverin family. |
| UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 2p25.1 Molecular Function:protein binding |
| NCBI Summary: | The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | P37235 |
| NCBI GenInfo Identifier: | 20455519 |
| NCBI Gene ID: | 3241 |
| NCBI Accession: | P37235.3 |
| UniProt Secondary Accession: | P37235,Q969S5, |
| UniProt Related Accession: | P37235 |
| Molecular Weight: | 22,313 Da |
| NCBI Full Name: | Hippocalcin-like protein 1 |
| NCBI Synonym Full Names: | hippocalcin like 1 |
| NCBI Official Symbol: | HPCAL1 |
| NCBI Official Synonym Symbols: | BDR1; HLP2; VILIP-3 |
| NCBI Protein Information: | hippocalcin-like protein 1 |
| UniProt Protein Name: | Hippocalcin-like protein 1 |
| UniProt Synonym Protein Names: | Calcium-binding protein BDR-1; HLP2; Visinin-like protein 3; VILIP-3 |
| Protein Family: | Hippocalcin-like protein |
| UniProt Gene Name: | HPCAL1 |
| UniProt Entry Name: | HPCL1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HPCAL1 antibody (CAB10019) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunoprecipitation analysis of extracts of HepG2 cells using HPCAL1 antibody (CAB10019). Western blot was performed from the immunoprecipitate using HPCAL1 antibody (CAB10019) at a dilition of 1:1000. |
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