Cell Biology Antibodies 12
Anti-HOOK2 Antibody (CAB8210)
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- SKU:
- CAB8210
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | HOOK2 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8210 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 438-717 of human HOOK2 (NP_001093646.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-431, Mouse stomach, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 438-717 of human HOOK2 (NP_001093646.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LDPT STPV DNLA AEIL PAEL RETL LRLQ LENK RLCR QEAA DRER QEEL QRHL EDAN RARH GLET QHRL NQQQ LSEL RAQV EDLQ KALQ EQGG KTED SILL KRKL EEHL QKLH EADL ELQR KREY IEEL EPPT DSST ARRI EELQ HNLQ KKDA DLRA MEER YRRY VDKA RMVM QTME PKQR PAAG APPE LHSL RTQL RERD VRIR HLEM DFEK SRSQ REQE EKLL ISAW YNMG MALQ QRAG EERA PAHA QSFL AQQR LATN SRRG PLGR LASL NLRP TDKH |
| Gene ID: | 29911 |
| Uniprot: | Q96ED9 |
| Cellular Location: | Cytoplasm, centrosome, cytoskeleton, microtubule organizing center |
| Calculated MW: | 83kDa |
| Observed MW: | 100kDa |
| Synonyms: | HOOK2, HK2 |
| Background: |
| UniProt Protein Function: | HOOK2: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. Belongs to the hook family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: centrosome Molecular Function:identical protein binding; protein binding Biological Process: early endosome to late endosome transport; endocytosis; endosome organization and biogenesis; endosome to lysosome transport; lysosome organization and biogenesis |
| NCBI Summary: | Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004] |
| UniProt Code: | Q96ED9 |
| NCBI GenInfo Identifier: | 296439323 |
| NCBI Gene ID: | 29911 |
| NCBI Accession: | Q96ED9.3 |
| UniProt Secondary Accession: | Q96ED9,O60562, |
| UniProt Related Accession: | Q96ED9 |
| Molecular Weight: | 83,022 Da |
| NCBI Full Name: | Protein Hook homolog 2 |
| NCBI Synonym Full Names: | hook microtubule tethering protein 2 |
| NCBI Official Symbol: | HOOK2 |
| NCBI Official Synonym Symbols: | HK2 |
| NCBI Protein Information: | protein Hook homolog 2 |
| UniProt Protein Name: | Protein Hook homolog 2 |
| Protein Family: | Protein Hook |
| UniProt Gene Name: | HOOK2 |
| UniProt Entry Name: | HOOK2_HUMAN |
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