Developmental Biology
Anti-HOOK1 Antibody (CAB4731)
- SKU:
- CAB4731
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HOOK1
- Synonyms:
- HK1
- Research Area:
- Developmental Biology
Description
| Product Name: | HOOK1 Rabbit pAb |
| Product Code: | CAB4731 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | HOOK1, HK1 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 489-728 of human HOOK1 (NP_056972.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, MCF7, 22Rv1, Mouse liver, Mouse kidney, Mouse brain, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 489-728 of human HOOK1 (NP_056972.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IEEL QEQL EQKH RKMN ELET EQRL SKER IREL QQQI EDLQ KSLQ EQGS KSEG ESSS KLKQ KLEA HMEK LTEV HEEL QKKQ ELIE DLQP DINQ NVQK INEL EAAL QKKD EDMK AMEE RYKM YLEK ARNV IKTL DPKL NPAS AEIM LLRK QLAE KERR IEIL ESEC KVAK FRDY EEKL IVSA WYNK SLAF QKLG MESR LVSG GGAC SDTG ACTP ARSF LAQQ RHIT NTRR NLSV KVPA TTSD |
| Gene ID: | 51361 |
| Uniprot: | Q9UJC3 |
| Cellular Location: | Cytoplasm, cytoskeleton |
| Calculated MW: | 80kDa/84kDa |
| Observed MW: | 85-100kDa |
| UniProt Protein Function: | HOOK1: Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Belongs to the hook family. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 1p32.1 Molecular Function:identical protein binding; protein binding Biological Process: early endosome to late endosome transport; endosome organization and biogenesis; endosome to lysosome transport; lysosome organization and biogenesis |
| NCBI Summary: | This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UJC3 |
| NCBI GenInfo Identifier: | 41688595 |
| NCBI Gene ID: | 51361 |
| NCBI Accession: | Q9UJC3.2 |
| UniProt Secondary Accession: | Q9UJC3,O60561, Q5TG44, A8K8E9, A8MU44, B4DX15, |
| UniProt Related Accession: | Q9UJC3 |
| Molecular Weight: | 80,021 Da |
| NCBI Full Name: | Protein Hook homolog 1 |
| NCBI Synonym Full Names: | hook microtubule tethering protein 1 |
| NCBI Official Symbol: | HOOK1 |
| NCBI Official Synonym Symbols: | HK1 |
| NCBI Protein Information: | protein Hook homolog 1 |
| UniProt Protein Name: | Protein Hook homolog 1 |
| Protein Family: | Protein Hook |
| UniProt Gene Name: | HOOK1 |
| UniProt Entry Name: | HOOK1_HUMAN |
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