KO Validated Antibodies 2

Anti-HNRNPR Antibody (CAB19999)[KO Validated]

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SKU:
CAB19999
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-HNRNPR Antibody [KO Validated]
Antibody SKU:CAB19999
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human HNRNPR.
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T
Immunogen:A synthetic peptide of human HNRNPR.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10236
Uniprot:O43390
Cellular Location:Cytoplasm, Nucleus, nucleoplasm
Calculated MW:59kDa/66kDa/70kDa/71kDa
Observed MW:69KDa/82KDa
Anti-HNRNPR Antibody [KO Validated] (CAB19999)Western blot analysis of extracts from normal (control) and HNRNPR knockout (KO) 293T cells, using HNRNPR antibody (CAB19999) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Synonyms:HNRNPR, HNRPR, hnRNP-R
Background:This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10.
UniProt Protein Function:hnRNP R: Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA splicing; RNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: nucleolus; nucleoplasm; ribonucleoprotein complex

Molecular Function:protein binding

Biological Process: gene expression; nuclear mRNA splicing, via spliceosome

NCBI Summary:This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]
UniProt Code:O43390
NCBI GenInfo Identifier:12230547
NCBI Gene ID:10236
NCBI Accession:O43390.1
UniProt Secondary Accession:O43390,Q2L7G6, Q5TEH1, Q9BV64, S4R3J4,
UniProt Related Accession:O43390
Molecular Weight:59,953 Da
NCBI Full Name:Heterogeneous nuclear ribonucleoprotein R
NCBI Synonym Full Names:heterogeneous nuclear ribonucleoprotein R
NCBI Official Symbol:HNRNPR  
NCBI Official Synonym Symbols:HNRPR; hnRNP-R  
NCBI Protein Information:heterogeneous nuclear ribonucleoprotein R
UniProt Protein Name:Heterogeneous nuclear ribonucleoprotein R
Protein Family:Heterogeneous nuclear ribonucleoprotein
UniProt Gene Name:HNRNPR  
UniProt Entry Name:HNRPR_HUMAN
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