Developmental Biology

Anti-HLX Antibody (CAB13313)

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SKU:
CAB13313
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-HLX Antibody
Antibody SKU:CAB13313
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 80-280 of human HLX (NP_068777.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HL-60, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 80-280 of human HLX (NP_068777.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HPHA SFQA AARS PLRP TPVV APSE VPAG FPQR LSPL SAAY HHHH PQQQ QQQQ QPQQ QQPP PPPR AGAL QPPA SGTR VVPN PHHS GSAP APSS KDLK FGID RILS AEFD PKVK EGNT LRDL TSLL TGGR PAGV HLSG LQPS AGQF FASL DPIN EASA ILSP LNSN PRNS VQHQ FQDT FPGP YAVL TKDT MPQT YKRK RSWS R
Gene ID:3142
Uniprot:Q14774
Cellular Location:Nucleus
Calculated MW:50kDa
Observed MW:51kDa
Synonyms:HLX, HB24, HLX1
Background:
UniProt Protein Function:HLX: Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis. Belongs to the H2.0 homeobox family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: nucleus

Molecular Function:protein binding; sequence-specific DNA binding

Biological Process: negative regulation of T-helper 2 cell differentiation; skeletal muscle development; transcription, DNA-dependent; regulation of transcription, DNA-dependent; embryonic digestive tract morphogenesis; multicellular organismal development; positive regulation of cell proliferation; liver development; cell differentiation; positive regulation of T-helper 1 cell differentiation; enteric nervous system development; positive regulation of organ growth

UniProt Code:Q14774
NCBI GenInfo Identifier:160291960
NCBI Gene ID:3142
NCBI Accession:Q14774.3
UniProt Secondary Accession:Q14774,Q15988, Q59HE7, Q9NZ75, B2R8A8,
UniProt Related Accession:Q14774
Molecular Weight:488
NCBI Full Name:H2.0-like homeobox protein
NCBI Synonym Full Names:H2.0-like homeobox
NCBI Official Symbol:HLX  
NCBI Official Synonym Symbols:HB24; HLX1  
NCBI Protein Information:H2.0-like homeobox protein; H2.0-like homeobox 1; H2.0-like homeo box 1; H2.0-like homeo box-1; homeobox protein HB24; homeobox protein HLX1
UniProt Protein Name:H2.0-like homeobox protein
UniProt Synonym Protein Names:Homeobox protein HB24; Homeobox protein HLX1
Protein Family:H2.0-like homeobox protein
UniProt Gene Name:HLX  
UniProt Entry Name:HLX_HUMAN
Anti-HLX Antibody (CAB13313)Western blot analysis of extracts of various cell lines, using HLX antibody (CAB13313) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.
Anti-HLX Antibody (CAB13313)Immunofluorescence analysis of A549 cells using HLX antibody (CAB13313). Blue: DAPI for nuclear staining.
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