Name: Anti-Histone H1.0 Antibody (CAB4342)
Brand: Cell Biology Antibodies 17
SKU: CAB4342
Availability: OutOfStock

Antibody Name:	Anti-Histone H1.0 Antibody
Antibody SKU:	CAB4342
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthesized peptide derived from human Histone H1.0

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	HeLa, HT-29, SH-SY5Y, Mouse testis

Immunogen:	A synthesized peptide derived from human Histone H1.0
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	3005
Uniprot:	P07305
Cellular Location:
Calculated MW:	28kDa
Observed MW:	32KDa

Synonyms:

H10, H1FV

Background:

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]

UniProt Protein Function:	H1F0: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division. Belongs to the histone H1/H5 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:DNA-binding Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: nucleoplasm; Golgi apparatus; nuclear chromatin; nucleosome; nucleus; actin cytoskeleton Molecular Function:protein binding; chromatin DNA binding Biological Process: nucleosome assembly; apoptosis; DNA fragmentation during apoptosis; cell structure disassembly during apoptosis
NCBI Summary:	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H1 family. [provided by RefSeq, Jul 2008]
UniProt Code:	P07305
NCBI GenInfo Identifier:	121897
NCBI Gene ID:	3005
NCBI Accession:	P07305.3
UniProt Secondary Accession:	P07305,Q6FG88, Q8N6R3, B2R6I0, B4DRD6,
UniProt Related Accession:	P07305
Molecular Weight:	194
NCBI Full Name:	Histone H1.0
NCBI Synonym Full Names:	H1 histone family, member 0
NCBI Official Symbol:	H1F0
NCBI Official Synonym Symbols:	H10; H1FV
NCBI Protein Information:	histone H1.0; histone H1'; histone H1(0); H1.0, H1(0), H1-0
UniProt Protein Name:	Histone H1.0
UniProt Synonym Protein Names:	Histone H1'; Histone H1(0)Histone H1.0, N-terminally processed
Protein Family:	Histone
UniProt Gene Name:	H1F0
UniProt Entry Name:	H10_HUMAN