Cell Biology Antibodies 15
Anti-HIF3A Antibody (CAB20020)
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- SKU:
- CAB20020
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-HIF3A Antibody |
| Antibody SKU: | CAB20020 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human HIF3A. |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HUVEC, mouse heart, rat brain, rat liver |
| Immunogen: | Recombinant protein of human HIF3A. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 64344 |
| Uniprot: | Q9Y2N7 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | |
| Observed MW: | 64kDa |
| Synonyms: | HIF-3A, HIF3-alpha-1, IPAS, MOP7, PASD7, bHLHe17 |
| Background: | The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011] |
| UniProt Protein Function: | HIF3A: Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1. Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 4 has a dominant-negative function of inactivating HIF1A-mediated transcription. Isoform 4 attenuates the binding of HIF1A to hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of isoform 4, leading to activation of HIF1A in hypoxia. Conversely, upon restoring normoxia, the expression of isoform 4 increases and thereby secure an inhibition of HIF1A activity. Isoform 4 may be a negative regulator of hypoxia-inducible gene expression in the kidney and may be involved in renal tumorigenesis. Functions as an inhibitor of angiogenesis in the cornea. 7 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; Tumor suppressor Chromosomal Location of Human Ortholog: 19q13.32 Cellular Component: nucleoplasm; cytosol Molecular Function:protein dimerization activity; signal transducer activity; DNA binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; signal transduction |
| NCBI Summary: | The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011] |
| UniProt Code: | Q9Y2N7 |
| NCBI GenInfo Identifier: | 145558932 |
| NCBI Gene ID: | 64344 |
| NCBI Accession: | Q9Y2N7.2 |
| UniProt Secondary Accession: | Q9Y2N7,Q58A43, Q66K72, Q8WXA1, Q96K34, Q9H7Z9, Q9HAI2 B0M185, B4DNA2, |
| UniProt Related Accession: | Q9Y2N7 |
| Molecular Weight: | 64,359 Da |
| NCBI Full Name: | Hypoxia-inducible factor 3-alpha |
| NCBI Synonym Full Names: | hypoxia inducible factor 3, alpha subunit |
| NCBI Official Symbol: | HIF3A |
| NCBI Official Synonym Symbols: | IPAS; MOP7; PASD7; HIF-3A; bHLHe17 |
| NCBI Protein Information: | hypoxia-inducible factor 3-alpha; HIF3-alpha-1; member of PAS protein 7; inhibitory PAS domain protein; PAS domain-containing protein 7; basic-helix-loop-helix-PAS protein MOP7; class E basic helix-loop-helix protein 17 |
| UniProt Protein Name: | Hypoxia-inducible factor 3-alpha |
| UniProt Synonym Protein Names: | Basic-helix-loop-helix-PAS protein MOP7; Class E basic helix-loop-helix protein 17; bHLHe17; HIF3-alpha-1; Inhibitory PAS domain protein; IPAS; Member of PAS protein 7; PAS domain-containing protein 7 |
| Protein Family: | Hypoxia-inducible factor |
| UniProt Gene Name: | HIF3A |
| UniProt Entry Name: | HIF3A_HUMAN |
 | Western blot - HIF3A Rabbit pAb (CAB20020) |
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