Cell Death Antibodies 1

Granzyme B Rabbit Polyclonal Antibody (CAB2557)

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SKU:
CAB2557
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death
Antibody Type:
Polyclonal Antibody
Reactivity:
Human, Mouse
Synonyms:
C11, HLP, CCPI, CGL1, CSPB, SECT, CGL-1, CSP-B, CTLA1, CTSGL1, Granzyme B
Research Use:
Cell Death
Frequently bought together:

Description

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Granzyme B Antibody (CAB2557)

The Granzyme B Antibody (CAB2557) is a high-quality antibody developed for reliable detection and analysis of target proteins. Granzyme B is a serine protease found in cytotoxic lymphocytes, and is involved in inducing apoptosis in target cells.This antibody, raised in rabbits, is highly specific to Granzyme B and has been validated for use in various applications, including Western blot and immunohistochemistry. Its high reactivity with human samples makes it ideal for studies in immunology, cancer research, and autoimmune diseases.

This antibody is validated for use in WB, IHC-P, ELISA, IF-P applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:Granzyme B Antibody
SKU:CAB2557
Size:20μL, 100μL
Reactivity:Human, Mouse
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:YNPK NFSN DIML LQLE RKAK RTRA VQPL RLPS NKAQ VKPG QTCS VAGW GQTA PLGK HSHT LQEV KMTV QEDR KCES DLRH YYDS TIEL CVGD PEIK KTSF K
Tested Applications:WB IHC-P ELISA IF-P
Recommended Dilution:
WB1:500 - 1:1000
IF-P1:50 - 1:200
IHC-P1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:C11, HLP, CCPI, CGL1, CSPB, SECT, CGL-1, CSP-B, CTLA1, CTSGL1, Granzyme B
Positive Sample:THP-1, Mouse large intestine
Cellular Localization:Cytoplasmic Granule.
Calculated MW:28kDa
Observed MW:30kDa

This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis.

Purification MethodAffinity purification
Gene ID3002
RRIDAB_2764445
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates, using Granzyme B Rabbit pAb (CAB2557) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Mouse spleen using Granzyme B Rabbit pAb (CAB2557) at dilution of 1:100 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
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