Signal Transduction Antibodies 1

Anti-GUCA1B Antibody (CAB14739)

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SKU:
CAB14739
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-GUCA1B Antibody
Antibody SKU:CAB14739
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GUCA1B (NP_002089.4).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse eye, Rat eye
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GUCA1B (NP_002089.4).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGQE FSWE EAEA AGEI DVAE LQEW YKKF VMEC PSGT LFMH EFKR FFKV TDDE EASQ YVEG MFRA FDKN GDNT IDFL EYVA ALNL VLRG TLEH KLKW TFKI YDKD GNGC IDRL ELLN IVEG IYQL KKAC RREL QTEQ GQLL TPEE VVDR IFLL VDEN GDGQ LSLN EFVE GARR DKWV MKML QMDM NPSS WLAQ QRRK SAMF
Gene ID:2979
Uniprot:Q9UMX6
Cellular Location:Cell membrane
Calculated MW:23kDa
Observed MW:23kDa
Synonyms:GUCA1B, GCAP2, GUCA2, RP48
Background:The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa.
UniProt Protein Function:GCAP2: Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure. Defects in GUCA1B are the cause of retinitis pigmentosa type 48 (RP48). RP48 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
UniProt Protein Details:

Protein type:Calcium-binding

Chromosomal Location of Human Ortholog: 6p21.1

Biological Process: body fluid secretion; cell-cell signaling; receptor guanylyl cyclase signaling pathway; regulation of rhodopsin mediated signaling

Disease: Retinitis Pigmentosa 48

NCBI Summary:The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa. [provided by RefSeq, Nov 2009]
UniProt Code:Q9UMX6
NCBI GenInfo Identifier:116242507
NCBI Gene ID:2979
NCBI Accession:Q9UMX6.4
UniProt Secondary Accession:Q9UMX6,Q9NU15,
UniProt Related Accession:Q9UMX6
Molecular Weight:23,420 Da
NCBI Full Name:Guanylyl cyclase-activating protein 2
NCBI Synonym Full Names:guanylate cyclase activator 1B
NCBI Official Symbol:GUCA1B  
NCBI Official Synonym Symbols:RP48; GCAP2; GUCA2  
NCBI Protein Information:guanylyl cyclase-activating protein 2
UniProt Protein Name:Guanylyl cyclase-activating protein 2
UniProt Synonym Protein Names:Guanylate cyclase activator 1B
Protein Family:Guanylyl cyclase-activating protein
UniProt Gene Name:GUCA1B  
UniProt Entry Name:GUC1B_HUMAN
Anti-GUCA1B Antibody (CAB14739)Western blot analysis of extracts of various cell lines, using GUCA1B antibody (CAB14739) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 3min.
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