Antibody Name:	Anti-GSTA2 Antibody
Antibody SKU:	CAB7678
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-222 of human GSTA2 (NP_000837.3).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	Mouse liver, Mouse testis, Rat liver, Rat kidney

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-222 of human GSTA2 (NP_000837.3).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MAEK PKLH YSNI RGRM ESIR WLLA AAGV EFEE KFIK SAED LDKL RNDG YLMF QQVP MVEI DGMK LVQT RAIL NYIA SKYN LYGK DIKE KALI DMYI EGIA DLGE MILL LPFS QPEE QDAK LALI QEKT KNRY FPAF EKVL KSHG QDYL VGNK LSRA DIHL VELL YYVE ELDS SLIS SFPL LKAL KTRI SNLP TVKK FLQP GSPR KPPM DEKS LEES RKIF RF
Gene ID:	2939
Uniprot:	P09210
Cellular Location:	Cytoplasm
Calculated MW:	25kDa
Observed MW:	25kDa

Synonyms:

GSTA2, GST2, GSTA2-2, GTA2, GTH2

Background:

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.

UniProt Protein Function:	GSTA2: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Alpha family.
UniProt Protein Details:	Protein type:EC 2.5.1.18; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; Transferase; Other Amino Acids Metabolism - glutathione Chromosomal Location of Human Ortholog: 6p12.1 Cellular Component: cytosol Molecular Function:glutathione transferase activity; protein binding Biological Process: epithelial cell differentiation; glutathione metabolic process
NCBI Summary:	Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008]
UniProt Code:	P09210
NCBI GenInfo Identifier:	126302551
NCBI Gene ID:	2939
NCBI Accession:	P09210.4
UniProt Secondary Accession:	P09210,Q12759, Q16491, Q9NTY6,
UniProt Related Accession:	P09210
Molecular Weight:	25,664 Da
NCBI Full Name:	Glutathione S-transferase A2
NCBI Synonym Full Names:	glutathione S-transferase alpha 2
NCBI Official Symbol:	GSTA2
NCBI Official Synonym Symbols:	GST2; GTA2; GTH2; GSTA2-2
NCBI Protein Information:	glutathione S-transferase A2
UniProt Protein Name:	Glutathione S-transferase A2
UniProt Synonym Protein Names:	GST HA subunit 2; GST class-alpha member 2; GST-gamma; GSTA2-2; GTH2
Protein Family:	Glutathione S-transferase
UniProt Gene Name:	GSTA2
UniProt Entry Name:	GSTA2_HUMAN

	Western blot analysis of extracts of various cell lines, using GSTA2 antibody (CAB7678) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded human prostate cancer using GSTA2 antibody (CAB7678) at dilution of 1:100 (40x lens).