Cell Biology Antibodies 11

Anti-GRM4 Antibody (CAB7284)

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SKU:
CAB7284
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GRM4 Antibody
Antibody SKU:CAB7284
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 33-290 of human GRM4 (NP_000832.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse spinal cord, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 33-290 of human GRM4 (NP_000832.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KPKG HPHM NSIR IDGD ITLG GLFP VHGR GSEG KPCG ELKK EKGI HRLE AMLF ALDR INND PDLL PNIT LGAR ILDT CSRD THAL EQSL TFVQ ALIE KDGT EVRC GSGG PPII TKPE RVVG VIGA SGSS VSIM VANI LRLF KIPQ ISYA STAP DLSD NSRY DFFS RVVP SDTY QAQA MVDI VRAL KWNY VSTV ASEG SYGE SGVE AFIQ KSRE DGGV CIAQ SVKI PREP KAGE FDKI IRRL LETS NARA VIIF ANED DI
Gene ID:2914
Uniprot:Q14833
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:83kDa/86kDa/87kDa/88kDa/101kDa
Observed MW:115kDa
Synonyms:GRM4, GPRC1D, MGLUR4, mGlu4
Background:L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:mGluR4: metabotropic glutamate receptor 3, a G-protein coupled receptor for glutamate. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cell development/differentiation; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 3

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: presynaptic membrane; integral to plasma membrane; plasma membrane; terminal button; presynaptic active zone membrane; intracellular; cytoplasmic vesicle; dendritic shaft

Molecular Function:calmodulin binding; G-protein coupled receptor activity; group III metabotropic glutamate receptor activity; glutamate receptor activity; calcium-dependent protein binding

Biological Process: synaptic transmission; regulation of synaptic transmission, glutamatergic; positive regulation of MAPKKK cascade; activation of MAPK activity; neurotransmitter secretion; regulation of neuron apoptosis; learning; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway

NCBI Summary:L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Code:Q14833
NCBI GenInfo Identifier:2495077
NCBI Gene ID:2914
NCBI Accession:Q14833.1
UniProt Secondary Accession:Q14833,Q5SZ84, Q6ZMQ2, B3KVL9, B7Z1T9, B7Z1U6, F5GXM5
UniProt Related Accession:Q14833,AAB34891
Molecular Weight:
NCBI Full Name:Metabotropic glutamate receptor 4
NCBI Synonym Full Names:glutamate receptor, metabotropic 4
NCBI Official Symbol:GRM4  
NCBI Official Synonym Symbols:mGlu4; GPRC1D; MGLUR4  
NCBI Protein Information:metabotropic glutamate receptor 4
UniProt Protein Name:Metabotropic glutamate receptor 4
Protein Family:Metabotropic glutamate receptor
UniProt Gene Name:GRM4  
UniProt Entry Name:GRM4_HUMAN
Anti-GRM4 Antibody (CAB7284)Western blot analysis of extracts of various cell lines, using GRM4 antibody (CAB7284) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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