Anti-GRK3 Antibody (CAB9163)
- SKU:
- CAB9163
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ADRBK2
- Synonyms:
- BARK2
- Research Area:
- Cell Biology
Description
| Product Name: | GRK3 Rabbit mAb |
| Product Code: | CAB9163 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ADRBK2, BARK2 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human GRK3 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | Jurkat, SH-SY5Y |
| Immunogen: | A synthesized peptide derived from human GRK3 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 157 |
| Uniprot: | P35626 |
| Calculated MW: | 80kDa |
| Observed MW: | 80KDa |
| UniProt Protein Function: | GRK3: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; EC 2.7.11.15; Kinase, protein; AGC group; GRK family; BARK subfamily Chromosomal Location of Human Ortholog: 22q12.1 Molecular Function:ATP binding; beta-adrenergic receptor kinase activity; G-protein coupled receptor kinase activity; protein kinase activity Biological Process: protein amino acid phosphorylation; receptor internalization; signal transduction |
| NCBI Summary: | The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P35626 |
| NCBI GenInfo Identifier: | 116241253 |
| NCBI Gene ID: | 157 |
| NCBI Accession: | P35626.2 |
| UniProt Secondary Accession: | P35626,Q9UGW9, |
| UniProt Related Accession: | P35626 |
| Molecular Weight: | 79,710 Da |
| NCBI Full Name: | Beta-adrenergic receptor kinase 2 |
| NCBI Synonym Full Names: | adrenergic, beta, receptor kinase 2 |
| NCBI Official Symbol: | ADRBK2 |
| NCBI Official Synonym Symbols: | GRK3; BARK2 |
| NCBI Protein Information: | beta-adrenergic receptor kinase 2 |
| UniProt Protein Name: | Beta-adrenergic receptor kinase 2 |
| UniProt Synonym Protein Names: | G-protein-coupled receptor kinase 3 |
| Protein Family: | Beta-adrenergic receptor kinase |
| UniProt Gene Name: | ADRBK2 |
| UniProt Entry Name: | ARBK2_HUMAN |
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