Signal Transduction Antibodies 1

Anti-GRIN3B Antibody (CAB10081)

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SKU:
CAB10081
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-GRIN3B Antibody
Antibody SKU:CAB10081
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 180-410 of human GRIN3B (NP_619635.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Rat
Positive Samples:Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 180-410 of human GRIN3B (NP_619635.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RTQD PGGL VALW TSRA GRPP QLVL DLSR RDTG DAGL RARL APMA APVG GEAP VPAA VLLG CDIA RARR VLEA VPPG PHWL LGTP LPPK ALPT AGLP PGLL ALGE VARP PLEA AIHD IVQL VARA LGSA AQVQ PKRA LLPA PVNC GDLQ PAGP ESPG RFLA RFLA NTSF QGRT GPVW VTGS SQVH MSRH FKVW SLRR DPRG APAW ATVG SWRD GQLD LEPG GASA RPPP PQG
Gene ID:116444
Uniprot:O60391
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Calculated MW:112kDa
Observed MW:135kDa
Synonyms:GRIN3B, GluN3B, NR3B, NMDA 3B
Background:The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia.
UniProt Protein Function:NMDAR3B: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3B/GRIN3B subfamily.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cell soma; N-methyl-D-aspartate selective glutamate receptor complex

Molecular Function:calcium channel activity; cation channel activity; glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; neurotransmitter binding; neurotransmitter receptor activity

Biological Process: ionotropic glutamate receptor signaling pathway; protein insertion into membrane; regulation of calcium ion transport

NCBI Summary:The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia. [provided by RefSeq, Nov 2015]
UniProt Code:O60391
NCBI GenInfo Identifier:71153527
NCBI Gene ID:116444
NCBI Accession:O60391.2
UniProt Secondary Accession:O60391,Q5EAK7, Q7RTW9,
UniProt Related Accession:O60391
Molecular Weight:112,992 Da
NCBI Full Name:Glutamate receptor ionotropic, NMDA 3B
NCBI Synonym Full Names:glutamate ionotropic receptor NMDA type subunit 3B
NCBI Official Symbol:GRIN3B  
NCBI Official Synonym Symbols:NR3B; GluN3B  
NCBI Protein Information:glutamate receptor ionotropic, NMDA 3B
UniProt Protein Name:Glutamate receptor ionotropic, NMDA 3B
UniProt Synonym Protein Names:N-methyl-D-aspartate receptor subtype 3B; NMDAR3B; NR3B
Protein Family:Glutamate receptor ionotropic
UniProt Gene Name:GRIN3B  
UniProt Entry Name:NMD3B_HUMAN
Anti-GRIN3B Antibody (CAB10081)Western blot analysis of extracts of rat brain, using GRIN3B antibody (CAB10081) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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