Name: Anti-GRIN2D Antibody (CAB10080)
Brand: Signal Transduction Antibodies 1
SKU: CAB10080
Availability: OutOfStock

Antibody Name:	Anti-GRIN2D Antibody
Antibody SKU:	CAB10080
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 330-480 of human GRIN2D (NP_000827.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	SH-SY5Y, Mouse liver

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 330-480 of human GRIN2D (NP_000827.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	GAQA LLRD YGFL PELG HDCR AQNR THRG ESLH RYFM NITW DNRD YSFN EDGF LVNP SLVV ISLT RDRT WEVV GSWE QQTL RLKY PLWS RYGR FLQP VDDT QHLT VATL EERP FVIV EPAD PISG TCIR DSVP CRSQ LNRT HSPP PDAP RPE
Gene ID:	2906
Uniprot:	O15399
Cellular Location:	Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Calculated MW:	143kDa
Observed MW:	170kDa

Synonyms:

GRIN2D, EB11, EIEE46, GluN2D, NMDAR2D, NR2D, NMDA 2D

Background:

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).

UniProt Protein Function:	NMDAR2D: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily.
UniProt Protein Details:	Protein type:Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: cell junction; intracellular; N-methyl-D-aspartate selective glutamate receptor complex; plasma membrane; postsynaptic membrane Molecular Function:extracellular-glutamate-gated ion channel activity; N-methyl-D-aspartate selective glutamate receptor activity; protein binding Biological Process: activation of MAPKK activity; adult locomotory behavior; axon guidance; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; ionotropic glutamate receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; Ras protein signal transduction; regulation of sensory perception of pain; signal transduction; small GTPase mediated signal transduction; startle response; synaptic transmission; vascular endothelial growth factor receptor signaling pathway
NCBI Summary:	N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]
UniProt Code:	O15399
NCBI GenInfo Identifier:	229462910
NCBI Gene ID:	2906
NCBI Accession:	O15399.2
UniProt Secondary Accession:	O15399,Q03391, Q62645,
UniProt Related Accession:	O15399
Molecular Weight:	143,752 Da
NCBI Full Name:	Glutamate receptor ionotropic, NMDA 2D
NCBI Synonym Full Names:	glutamate ionotropic receptor NMDA type subunit 2D
NCBI Official Symbol:	GRIN2D
NCBI Official Synonym Symbols:	EB11; NR2D; GluN2D; NMDAR2D
NCBI Protein Information:	glutamate receptor ionotropic, NMDA 2D
UniProt Protein Name:	Glutamate receptor ionotropic, NMDA 2D
UniProt Synonym Protein Names:	EB11; Glutamate [NMDA] receptor subunit epsilon-4; N-methyl D-aspartate receptor subtype 2D; NMDAR2D; NR2D
Protein Family:	Glutamate receptor ionotropic
UniProt Gene Name:	GRIN2D
UniProt Entry Name:	NMDE4_HUMAN

Western blot analysis of extracts of various cell lines, using GRIN2D antibody (CAB10080) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.

Antibodies

GRIN2D Antibody (PACO02798)

GRIN2D Antibody (PACO03984)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)