Signal Transduction Antibodies 1

Anti-GRIN2C Antibody (CAB14241)

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SKU:
CAB14241
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-GRIN2C Antibody
Antibody SKU:CAB14241
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-350 of human GRIN2C (NP_000826.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Mouse
Positive Samples:Mouse brain, Mouse pancreas
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-350 of human GRIN2C (NP_000826.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GLGP GQGE QGMT VAVV FSSS GPPQ AQFR ARLT PQSF LDLP LEIQ PLTV GVNT TNPS SLLT QICG LLGA AHVH GIVF EDNV DTEA VAQI LDFI SSQT HVPI LSIS GGSA VVLT PKEP GSAF LQLG VSLE QQLQ VLFK VLEE YDWS AFAV ITSL HPGH ALFL EGVR AVAD ASHV SWRL LDVV TLEL GPGG PRAR TQRL LRQL DAPV FVAY CSRE EAEV LFAE AAQA GLVG PGHV WLVP NLAL GSTD APPA TFPV GLIS VVTE SWRL SLRQ KVRD GVAI LALG AHSY WRQH GTLP APAG DCRV HPGP VSPA REAF YRHL LNVT WEGR DFSF SPG
Gene ID:2905
Uniprot:Q14957
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Calculated MW:134kDa
Observed MW:134kDa
Synonyms:GRIN2C, GluN2C, NMDAR2C, NR2C, NMDA 2C
Background:This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:NMDAR2C: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: postsynaptic membrane; integral to plasma membrane; postsynaptic density; dendrite; plasma membrane; cell junction; N-methyl-D-aspartate selective glutamate receptor complex

Molecular Function:protein binding; extracellular-glutamate-gated ion channel activity; N-methyl-D-aspartate selective glutamate receptor activity; protein N-terminus binding; cation channel activity; PDZ domain binding

Biological Process: synaptic transmission; synaptic transmission, glutamatergic; protein localization; transport; directional locomotion; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; response to wounding; regulation of excitatory postsynaptic membrane potential; neuromuscular process controlling balance; negative regulation of protein catabolic process

NCBI Summary:This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
UniProt Code:Q14957
NCBI GenInfo Identifier:55770854
NCBI Gene ID:2905
NCBI Accession:NP_000826.2
UniProt Secondary Accession:Q14957,B2RTT1,
UniProt Related Accession:Q14957
Molecular Weight:134,209 Da
NCBI Full Name:glutamate receptor ionotropic, NMDA 2C isoform 1
NCBI Synonym Full Names:glutamate receptor, ionotropic, N-methyl D-aspartate 2C
NCBI Official Symbol:GRIN2C  
NCBI Official Synonym Symbols:NR2C; GluN2C; NMDAR2C  
NCBI Protein Information:glutamate receptor ionotropic, NMDA 2C; N-methyl D-aspartate receptor subtype 2C; N-methyl-D-aspartate receptor subunit 2C; glutamate [NMDA] receptor subunit epsilon-3
UniProt Protein Name:Glutamate receptor ionotropic, NMDA 2C
UniProt Synonym Protein Names:Glutamate [NMDA] receptor subunit epsilon-3; N-methyl D-aspartate receptor subtype 2C
Protein Family:Glutamate receptor ionotropic
UniProt Gene Name:GRIN2C  
UniProt Entry Name:NMDE3_HUMAN
Anti-GRIN2C Antibody (CAB14241)Western blot analysis of extracts of various cell lines, using GRIN2C antibody (CAB14241) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.
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