Signal Transduction Antibodies 2

Anti-GRIK5 Antibody (CAB15676)

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SKU:
CAB15676
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-GRIK5 Antibody
Antibody SKU:CAB15676
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-420 of human GRIK5 (NP_002079.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:K-562, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-420 of human GRIK5 (NP_002079.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LRMV EYDG LTGR VEFN SKGQ RTNY TLRI LEKS RQGH REIG VWYS NRTL AMNA TTLD INLS QTLA NKTL VVT
Gene ID:2901
Uniprot:Q16478
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Calculated MW:109kDa
Observed MW:109kDa
Synonyms:GRIK5, EAA2, GRIK2, GluK5, KA2, kainate 5
Background:This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:GluR KA2: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate >> AMPA >> NMDA = 1S,3R-ACPD. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: plasma membrane

Molecular Function:kainate selective glutamate receptor activity; ligand-gated ion channel activity

NCBI Summary:This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Code:Q16478
NCBI GenInfo Identifier:209572626
NCBI Gene ID:2901
NCBI Accession:Q16478.2
UniProt Secondary Accession:Q16478,Q8WWG8,
UniProt Related Accession:Q16478
Molecular Weight:109,658 Da
NCBI Full Name:Glutamate receptor ionotropic, kainate 5
NCBI Synonym Full Names:glutamate ionotropic receptor kainate type subunit 5
NCBI Official Symbol:GRIK5  
NCBI Official Synonym Symbols:KA2; EAA2; GRIK2; GluK5  
NCBI Protein Information:glutamate receptor ionotropic, kainate 5
UniProt Protein Name:Glutamate receptor ionotropic, kainate 5
UniProt Synonym Protein Names:Excitatory amino acid receptor 2; EAA2; Glutamate receptor KA-2; KA2
Protein Family:Glutamate receptor ionotropic
UniProt Gene Name:GRIK5  
UniProt Entry Name:GRIK5_HUMAN
Anti-GRIK5 Antibody (CAB15676)Western blot analysis of extracts of various cell lines, using GRIK5 antibody (CAB15676) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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