Signal Transduction Antibodies 2
Anti-GRIK5 Antibody (CAB15676)
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- SKU:
- CAB15676
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-GRIK5 Antibody |
| Antibody SKU: | CAB15676 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-420 of human GRIK5 (NP_002079.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | K-562, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-420 of human GRIK5 (NP_002079.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LRMV EYDG LTGR VEFN SKGQ RTNY TLRI LEKS RQGH REIG VWYS NRTL AMNA TTLD INLS QTLA NKTL VVT |
| Gene ID: | 2901 |
| Uniprot: | Q16478 |
| Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| Calculated MW: | 109kDa |
| Observed MW: | 109kDa |
| Synonyms: | GRIK5, EAA2, GRIK2, GluK5, KA2, kainate 5 |
| Background: | This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | GluR KA2: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate >> AMPA >> NMDA = 1S,3R-ACPD. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: plasma membrane Molecular Function:kainate selective glutamate receptor activity; ligand-gated ion channel activity |
| NCBI Summary: | This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q16478 |
| NCBI GenInfo Identifier: | 209572626 |
| NCBI Gene ID: | 2901 |
| NCBI Accession: | Q16478.2 |
| UniProt Secondary Accession: | Q16478,Q8WWG8, |
| UniProt Related Accession: | Q16478 |
| Molecular Weight: | 109,658 Da |
| NCBI Full Name: | Glutamate receptor ionotropic, kainate 5 |
| NCBI Synonym Full Names: | glutamate ionotropic receptor kainate type subunit 5 |
| NCBI Official Symbol: | GRIK5 |
| NCBI Official Synonym Symbols: | KA2; EAA2; GRIK2; GluK5 |
| NCBI Protein Information: | glutamate receptor ionotropic, kainate 5 |
| UniProt Protein Name: | Glutamate receptor ionotropic, kainate 5 |
| UniProt Synonym Protein Names: | Excitatory amino acid receptor 2; EAA2; Glutamate receptor KA-2; KA2 |
| Protein Family: | Glutamate receptor ionotropic |
| UniProt Gene Name: | GRIK5 |
| UniProt Entry Name: | GRIK5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GRIK5 antibody (CAB15676) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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