Signal Transduction Antibodies 1

Anti-GRIK4 Antibody (CAB13800)

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SKU:
CAB13800
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-GRIK4 Antibody
Antibody SKU:CAB13800
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-220 of human GRIK4 (NP_055434.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, Mouse brain, Mouse kidney, Rat brain, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-220 of human GRIK4 (NP_055434.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SPHS LRIA AILD DPME CSRG ERLS ITLA KNRI NRAP ERLG KAKV EVDI FELL RDSE YETA ETMC QILP KGVV AVLG PSSS PASS SIIS NICG EKEV PHFK VAPE EFVK FQFQ RFTT LNLH PSNT DISV AVAG ILNF FNCT TACL ICAK AECL LNLE KLLR QFLI SKDT LSVR MLDD TRDP TPLL KEIR DDKT ATII IHAN
Gene ID:2900
Uniprot:Q16099
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Calculated MW:107kDa
Observed MW:100kDa
Synonyms:GRIK4, EAA1, GRIK, GluK4, KA1, kainate 4
Background:This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:GluR KA1: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily.
UniProt Protein Details:

Protein type:Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: presynaptic membrane; postsynaptic membrane; kainate selective glutamate receptor complex; integral to plasma membrane; dendrite; plasma membrane; terminal button; perikaryon; cell junction; nucleus

Molecular Function:extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity

Biological Process: synaptic transmission; synaptic transmission, glutamatergic; glutamate signaling pathway; transport; ionotropic glutamate receptor signaling pathway; response to corticosteroid stimulus

NCBI Summary:This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
UniProt Code:Q16099
NCBI GenInfo Identifier:209572625
NCBI Gene ID:2900
NCBI Accession:Q16099.2
UniProt Secondary Accession:Q16099,Q8BMF5, Q01812,
UniProt Related Accession:Q16099
Molecular Weight:107,246 Da
NCBI Full Name:Glutamate receptor ionotropic, kainate 4
NCBI Synonym Full Names:glutamate receptor, ionotropic, kainate 4
NCBI Official Symbol:GRIK4  
NCBI Official Synonym Symbols:KA1; EAA1; GRIK; GluK4  
NCBI Protein Information:glutamate receptor ionotropic, kainate 4; glutamate receptor KA1; glutamate receptor KA-1; excitatory amino acid receptor 1
UniProt Protein Name:Glutamate receptor ionotropic, kainate 4
UniProt Synonym Protein Names:Excitatory amino acid receptor 1; EAA1; Glutamate receptor KA-1; KA1
UniProt Gene Name:GRIK4  
UniProt Entry Name:GRIK4_HUMAN
Anti-GRIK4 Antibody (CAB13800)Western blot analysis of extracts of various cell lines, using GRIK4 antibody (CAB13800) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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