Signal Transduction Antibodies 1
Anti-GRIA3 Antibody (CAB1159)
- SKU:
- CAB1159
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
Antibody Name: | Anti-GRIA3 Antibody |
Antibody SKU: | CAB1159 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC IF |
Reactivity: | Human, Mouse |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-490 of human GRIA3 (NP_000819.3). |
Application: | WB IHC IF |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
Reactivity: | Human, Mouse |
Positive Samples: | U-251MG, PC-3, Mouse brain, Mouse lung |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-490 of human GRIA3 (NP_000819.3). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | QEFR RIIE EMDR RQEK RYLI DCEV ERIN TILE QVVI LGKH SRGY HYML ANLG FTDI LLER VMHG GANI TGFQ IVNN ENPM VQQF IQRW VRLD EREF PEAK NAPL KYTS ALTH DAIL VIAE AFRY LRRQ RVDV SRRG SAGD CLAN PAVP WSQG IDIE RALK MVQV QGMT GNIQ FDTY GRRT NYTI DVYE MKVS GSRK AGYW NEYE RFVP FSDQ QISN DSAS SENR TIVV TTIL ESPY VMYK KNHE QLEG NERY EGYC VDLA YEIA KHVR IKYK LSIV GDGK YGAR DPET KIW |
Gene ID: | 2892 |
Uniprot: | P42263 |
Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
Calculated MW: | 101kDa |
Observed MW: | 101kDa |
Synonyms: | GRIA3, GLUR-C, GLUR-K3, GLUR3, GLURC, GluA3, MRX94 |
Background: | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. |
UniProt Protein Function: | GluR3: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Interacts with protein kinase C-alpha binding protein. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated Chromosomal Location of Human Ortholog: Xq25 Cellular Component: postsynaptic membrane; dendrite; plasma membrane; cell junction Molecular Function:extracellular-glutamate-gated ion channel activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Biological Process: synaptic transmission, glutamatergic; synaptic transmission; transport; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway Disease: Mental Retardation, X-linked, Syndromic, Wu Type |
NCBI Summary: | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008] |
UniProt Code: | P42263 |
NCBI GenInfo Identifier: | 77416864 |
NCBI Gene ID: | 2892 |
NCBI Accession: | P42263.2 |
UniProt Secondary Accession: | P42263,Q4VXD5, Q4VXD6, Q9HDA0, Q9HDA1, Q9HDA2, Q9P0H1 D3DTF1, |
UniProt Related Accession: | P42263 |
Molecular Weight: | 101,228 Da |
NCBI Full Name: | Glutamate receptor 3 |
NCBI Synonym Full Names: | glutamate receptor, ionotropic, AMPA 3 |
NCBI Official Symbol: | GRIA3 |
NCBI Official Synonym Symbols: | GLUR3; GLURC; GluA3; MRX94; GLUR-C; GLUR-K3 |
NCBI Protein Information: | glutamate receptor 3; gluR-3; dJ1171F9.1; glutamate receptor C; glutamate receptor subunit 3; AMPA-selective glutamate receptor 3; glutamate receptor, ionotrophic, AMPA 3 |
UniProt Protein Name: | Glutamate receptor 3 |
UniProt Synonym Protein Names: | AMPA-selective glutamate receptor 3; GluR-C; GluR-K3; Glutamate receptor ionotropic, AMPA 3; GluA3 |
Protein Family: | Glutamate receptor |
UniProt Gene Name: | GRIA3 |
UniProt Entry Name: | GRIA3_HUMAN |
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