Cell Biology Antibodies 9
Anti-GNRH1 Antibody (CAB5625)
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- SKU:
- CAB5625
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GNRH1 Antibody |
| Antibody SKU: | CAB5625 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-92 of human GNRH1 (NP_001076580.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-92 of human GNRH1 (NP_001076580.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QHWS YGLR PGGK RDAE NLID SFQE IVKE VGQL AETQ RFEC TTHQ PRSP LRDL KGAL ESLI EEET GQKK I |
| Gene ID: | 2796 |
| Uniprot: | P01148 |
| Cellular Location: | Secreted |
| Calculated MW: | 10kDa |
| Observed MW: | 12kDa |
| Synonyms: | GNRH1, GNRH, GRH, LHRH, LNRH |
| Background: | This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. |
| UniProt Protein Function: | Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.MiscellaneousThe 3D-structure was determined for the synthetic analog Triptorelin. |
| NCBI Summary: | This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015] |
| UniProt Code: | P01148 |
| NCBI GenInfo Identifier: | 121522 |
| NCBI Gene ID: | 2796 |
| NCBI Accession: | P01148.1 |
| UniProt Secondary Accession: | P01148,A0AVP0, |
| UniProt Related Accession: | P01148 |
| Molecular Weight: | 10,380 Da |
| NCBI Full Name: | Progonadoliberin-1 |
| NCBI Synonym Full Names: | gonadotropin releasing hormone 1 |
| NCBI Official Symbol: | GNRH1 |
| NCBI Official Synonym Symbols: | GRH; GNRH; LHRH; LNRH |
| NCBI Protein Information: | progonadoliberin-1 |
| UniProt Protein Name: | Progonadoliberin-1 |
| UniProt Synonym Protein Names: | Progonadoliberin I |
| Protein Family: | Progonadoliberin |
| UniProt Gene Name: | GNRH1 |
 | Western blot analysis of extracts of various cell lines, using GNRH1 antibody (CAB5625) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human prostate using GNRH1 antibody (CAB5625) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using GNRH1 antibody (CAB5625) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of L929 cells using GNRH1 Rabbit pAb (CAB5625) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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