Cell Biology Antibodies 16
Anti-Glycophorin C Antibody (CAB11472)
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- SKU:
- CAB11472
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Glycophorin C Antibody |
| Antibody SKU: | CAB11472 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Glycophorin C |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | K-562, Mouse liver, Rat liver |
| Immunogen: | A synthesized peptide derived from human Glycophorin C |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2995 |
| Uniprot: | P04921 |
| Cellular Location: | Cell membrane, Single-pass type III membrane protein |
| Calculated MW: | 39kDa |
| Observed MW: | 30-40KDa |
 | Western blot - Glycophorin C Rabbit mAb (CAB11472) |
| Synonyms: | CD236, CD236R, GE, GE:GPC:GPD:GYPD, GPC, GPD, GYPD, PAS-2, PAS-2' |
| Background: | Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] |
| UniProt Protein Function: | GYPC: This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells. Belongs to the glycophorin-C family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 2q14-q21 Cellular Component: cortical cytoskeleton; membrane; integral to plasma membrane; plasma membrane Molecular Function:protein binding Disease: Malaria, Susceptibility To; Blood Group, Gerbich System |
| NCBI Summary: | Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] |
| UniProt Code: | P04921 |
| NCBI GenInfo Identifier: | 121407 |
| NCBI Gene ID: | 2995 |
| NCBI Accession: | P04921.1 |
| UniProt Secondary Accession: | P04921,Q53SV9, Q92642, B2R522, |
| UniProt Related Accession: | P04921 |
| Molecular Weight: | 128 |
| NCBI Full Name: | Glycophorin-C |
| NCBI Synonym Full Names: | glycophorin C (Gerbich blood group) |
| NCBI Official Symbol: | GYPC |
| NCBI Official Synonym Symbols: | GE; GPC; GPD; GYPD; CD236; PAS-2; CD236R; PAS-2' |
| NCBI Protein Information: | glycophorin-C; glycophorin-D; glycoconnectin; glycoprotein beta; sialoglycoprotein D |
| UniProt Protein Name: | Glycophorin-C |
| UniProt Synonym Protein Names: | Glycoconnectin; Glycophorin-D; GPD; Glycoprotein beta; PAS-2'; Sialoglycoprotein D; CD_antigen: CD236 |
| Protein Family: | Glycophorin |
| UniProt Gene Name: | GYPC |
| UniProt Entry Name: | GLPC_HUMAN |
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