Anti-Glycerol kinase (GK) Antibody (CAB19221)
- SKU:
- CAB19221
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- GK
- Synonyms:
- GK1
- Synonyms:
- GKD
- Synonyms:
- glycerol kinase
- Research Area:
- Metabolism
Description
| Product Name: | Glycerol kinase (GK) Rabbit mAb |
| Product Code: | CAB19221 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | GK, GK1, GKD, glycerol kinase |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human Glycerol kinase (GK) (GK). |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, U-87MG, Mouse testis, Rat liver, Rat testis, Rat kidney |
| Immunogen: | Recombinant protein of human Glycerol kinase (GK) (GK). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2710 |
| Uniprot: | P32189 |
| Cellular Location: | Cytoplasm, Cytoplasmic side, Mitochondrion outer membrane, Peripheral membrane protein |
| Calculated MW: | 50kDa |
| Observed MW: | 57KDa |
| UniProt Protein Function: | GLPK: Key enzyme in the regulation of glycerol uptake and metabolism. Defects in GK are the cause of GK deficiency (GKD). This disease can be either symptomatic with episodic metabolic and CNS decompensation or asymptomatic with hyperglycerolemia and hyperglyceroluria only. Belongs to the FGGY kinase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.7.1.30; Lipid Metabolism - glycerolipid; Mitochondrial; Kinase, other Chromosomal Location of Human Ortholog: Xp21.3 Cellular Component: mitochondrial outer membrane; cytosol; nucleus Molecular Function:glycerol kinase activity; protein binding; ATP binding Biological Process: triacylglycerol metabolic process; glycerol metabolic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; glucose homeostasis; phosphorylation; glycerol-3-phosphate biosynthetic process; glycerol catabolic process Disease: Glycerol Kinase Deficiency |
| NCBI Summary: | The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] |
| UniProt Code: | P32189 |
| NCBI GenInfo Identifier: | 205830913 |
| NCBI Gene ID: | 2710 |
| NCBI Accession: | P32189.3 |
| UniProt Secondary Accession: | P32189,Q6IQ27, Q8IVR5, Q9UMP0, Q9UMP1, A6NJP5, B2R833 |
| UniProt Related Accession: | P32189 |
| Molecular Weight: | 58,141 Da |
| NCBI Full Name: | Glycerol kinase |
| NCBI Synonym Full Names: | glycerol kinase |
| NCBI Official Symbol: | GK |
| NCBI Official Synonym Symbols: | GK1; GKD |
| NCBI Protein Information: | glycerol kinase; ATP:glycerol 3-phosphotransferase; glycerokinase |
| UniProt Protein Name: | Glycerol kinase |
| UniProt Synonym Protein Names: | ATP:glycerol 3-phosphotransferase |
| Protein Family: | Glycerol kinase |
| UniProt Gene Name: | GK |
| UniProt Entry Name: | GLPK_HUMAN |
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