Cell Biology Antibodies 4
Anti-GLYAT Antibody (CAB14100)
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- SKU:
- CAB14100
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GLYAT Antibody |
| Antibody SKU: | CAB14100 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-163 of human GLYAT (NP_005829.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-163 of human GLYAT (NP_005829.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MMLP LQGA QMLQ MLEK SLRK SLPA SLKV YGTV FHIN HGNP FNLK AVVD KWPD FNTV VVCP QEQD MTDD LDHY TNTY QIYS KDPQ NCQE FLGS PELI NWKQ HLQI QSSQ PSLN EAIQ NLAA IKSF KVKQ TQRI LYMA AETA KELT PFLL KSKI LSPN GGKP KAM |
| Gene ID: | 10249 |
| Uniprot: | Q6IB77 |
| Cellular Location: | Mitochondrion |
| Calculated MW: | 18kDa/33kDa |
| Observed MW: | 34kDa |
| Synonyms: | GLYAT, ACGNAT, CAT, GAT |
| Background: | The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | GLYAT: Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. Belongs to the glycine N-acyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.3.1.71; Transferase; Mitochondrial; EC 2.3.1.13 Chromosomal Location of Human Ortholog: 11q12.1 Cellular Component: mitochondrial matrix; mitochondrion Molecular Function:glycine N-benzoyltransferase activity; protein binding; transferase activity, transferring acyl groups Biological Process: acyl-CoA metabolic process; glycine metabolic process; monocarboxylic acid metabolic process; xenobiotic metabolic process |
| NCBI Summary: | The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6IB77 |
| NCBI GenInfo Identifier: | 311033446 |
| NCBI Gene ID: | 10249 |
| NCBI Accession: | Q6IB77.3 |
| UniProt Secondary Accession: | Q6IB77,O14833, Q96QK7, |
| UniProt Related Accession: | Q6IB77 |
| Molecular Weight: | 18,506 Da |
| NCBI Full Name: | Glycine N-acyltransferase |
| NCBI Synonym Full Names: | glycine-N-acyltransferase |
| NCBI Official Symbol: | GLYAT |
| NCBI Official Synonym Symbols: | CAT; GAT; ACGNAT |
| NCBI Protein Information: | glycine N-acyltransferase |
| UniProt Protein Name: | Glycine N-acyltransferase |
| UniProt Synonym Protein Names: | Acyl-CoA:glycine N-acyltransferase; AAc; Aralkyl acyl-CoA N-acyltransferase; Aralkyl acyl-CoA:amino acid N-acyltransferase; Benzoyl-coenzyme A:glycine N-acyltransferase; Glycine N-benzoyltransferase (EC:2.3.1.71 |
| Protein Family: | Glycine N-acyltransferase |
| UniProt Gene Name: | GLYAT |
| UniProt Entry Name: | GLYAT_HUMAN |
 | Western blot analysis of extracts of mouse liver, using GLYAT antibody (CAB14100) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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