Anti-GluN2A Antibody [N327A/38]

GluN2A Antibody [N327A/38]

GluN2A Antibody [N327A/38] is a mouse monoclonal antibody directed against GluN2A, offered by Assay Genie for research applications. Reported applications include WB, IHC and ICC/IF. Reported reactivity: Human, Mouse and Rat. Supplied as IgG2b, purified by Protein G.

NR2A (GRIN2A) is a subunit of the N-methyl-D-aspartate (NMDA) receptor, a glutamate-gated ion channel essential for synaptic plasticity, learning, and memory. NR2A-containing NMDA receptors are predominantly expressed in the postnatal and adult brain, where they contribute to fast synaptic transmission and long-term potentiation (LTP). NR2A plays a critical role in calcium influx and downstream signaling cascades that regulate gene expression, synaptic remodeling, and neuronal survival. Alterations in NR2A expression or function have been implicated in neurodegenerative diseases such as Alzheimer’s disease, where NMDA receptor dysregulation contributes to excitotoxicity and synaptic loss. In addition to its role in cognition, NR2A is involved in neurodevelopment and the fine-tuning of excitatory synaptic strength. Its interaction with scaffolding proteins and signaling molecules positions it as a key modulator of synaptic architecture and plasticity. Targeting NR2A-containing NMDA receptors offers a potential therapeutic strategy for modulating glutamatergic signaling in neurodegenerative and neuropsychiatric disorders. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.