Cell Biology Antibodies 10
Anti-GLUD2 Antibody (CAB6604)
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- SKU:
- CAB6604
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GLUD2 Antibody |
| Antibody SKU: | CAB6604 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 319-558 of human GLUD2 (NP_036216.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, MCF7, THP-1, A-431, Mouse brain, Mouse eye, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 319-558 of human GLUD2 (NP_036216.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YLHR FGAK CIAV GESD GSIW NPDG IDPK ELED FKLQ HGSI LGFP KAKP YEGS ILEV DCDI LIPA ATEK QLTK SNAP RVKA KIIA EGAN GPTT PEAD KIFL ERNI LVIP DLYL NAGG VTVS YFEW LKNL NHVS YGRL TFKY ERDS NYHL LLSV QESL ERKF GKHG GTIP IVPT AEFQ DSIS GASE KDIV HSAL AYTM ERSA RQIM HTAM KYNL GLDL RTAA YVNA IEKV FKVY SEAG VTFT |
| Gene ID: | 2747 |
| Uniprot: | P49448 |
| Cellular Location: | Mitochondrion matrix |
| Calculated MW: | 61kDa |
| Observed MW: | 55kDa |
| Synonyms: | GLUD2, GDH2, GLUDP1 |
| Background: | The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless. |
| UniProt Protein Function: | GLUD2: Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission. Homohexamer. Expressed in retina, testis and, at a lower level, brain. Belongs to the Glu/Leu/Phe/Val dehydrogenases family. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - alanine, aspartate and glutamate; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Amino Acid Metabolism - arginine and proline; EC 1.4.1.3; Mitochondrial; Oxidoreductase; Energy Metabolism - nitrogen Chromosomal Location of Human Ortholog: Xq24-q25 Cellular Component: mitochondrion; cytoplasm Molecular Function:glutamate dehydrogenase activity; glutamate dehydrogenase [NAD(P)+] activity; GTP binding; ADP binding Biological Process: glutamate catabolic process; glutamate metabolic process; glutamate biosynthetic process |
| NCBI Summary: | The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.[provided by RefSeq, Jan 2010] |
| UniProt Code: | P49448 |
| NCBI GenInfo Identifier: | 13432152 |
| NCBI Gene ID: | 2747 |
| NCBI Accession: | P49448.2 |
| UniProt Secondary Accession: | P49448,Q9UDQ4, B2R8G0, |
| UniProt Related Accession: | P49448 |
| Molecular Weight: | 558 |
| NCBI Full Name: | Glutamate dehydrogenase 2, mitochondrial |
| NCBI Synonym Full Names: | glutamate dehydrogenase 2 |
| NCBI Official Symbol: | GLUD2 |
| NCBI Official Synonym Symbols: | GDH2; GLUDP1 |
| NCBI Protein Information: | glutamate dehydrogenase 2, mitochondrial; GDH 2; glutamate dehydrogenase pseudogene 1 |
| UniProt Protein Name: | Glutamate dehydrogenase 2, mitochondrial |
| UniProt Gene Name: | GLUD2 |
| UniProt Entry Name: | DHE4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GLUD2 antibody (CAB6604) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using GLUD2 antibody (CAB6604) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver damage using GLUD2 antibody (CAB6604) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human esophageal cancer using GLUD2 antibody (CAB6604) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using GLUD2 antibody (CAB6604) at dilution of 1:100 (40x lens). |
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