Signal Transduction Antibodies 2
Anti-GLRA2 Antibody (CAB15673)
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- SKU:
- CAB15673
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-GLRA2 Antibody |
| Antibody SKU: | CAB15673 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-420 of human GLRA2 (NP_002054.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse spinal cord, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-420 of human GLRA2 (NP_002054.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RLRR RQKR QNKE EDVT RESR FNFS GYGM GHCL QVKD GTAV KATP ANPL PQPP KDGD AIKK KFVD RAKR IDT |
| Gene ID: | 2742 |
| Uniprot: | P23416 |
| Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| Calculated MW: | 42kDa/51kDa/52kDa |
| Observed MW: | 52kDa |
| Synonyms: | GLRA2, GLR |
| Background: | The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | GLRA2: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA2 sub- subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, ion channel Chromosomal Location of Human Ortholog: Xp22.2 Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction Molecular Function:transmitter-gated ion channel activity; extracellular-glycine-gated chloride channel activity; glycine binding Biological Process: neuropeptide signaling pathway; ion transport; transmembrane transport |
| NCBI Summary: | The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010] |
| UniProt Code: | P23416 |
| NCBI GenInfo Identifier: | 121578 |
| NCBI Gene ID: | 2742 |
| NCBI Accession: | P23416.1 |
| UniProt Secondary Accession: | P23416,Q7TNC8, P22771, |
| UniProt Related Accession: | P23416 |
| Molecular Weight: | 452 |
| NCBI Full Name: | Glycine receptor subunit alpha-2 |
| NCBI Synonym Full Names: | glycine receptor, alpha 2 |
| NCBI Official Symbol: | GLRA2 |
| NCBI Official Synonym Symbols: | GLR |
| NCBI Protein Information: | glycine receptor subunit alpha-2; glycine receptor alpha 2 subunit; glycine receptor, alpha-2 polypeptide |
| UniProt Protein Name: | Glycine receptor subunit alpha-2 |
| Protein Family: | Glycine receptor |
| UniProt Gene Name: | GLRA2 |
| UniProt Entry Name: | GLRA2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GLRA2 antibody (CAB15673) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 1s. |
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