Cell Biology Antibodies 12
Anti-GHRHR Antibody (CAB8421)
- SKU:
- CAB8421
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GHRHR Antibody |
| Antibody SKU: | CAB8421 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human GHRHR (NP_000814.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-251MG, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human GHRHR (NP_000814.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDRR MWGA HVFC VLSP LPTV LGHM HPEC DFIT QLRE DESA CLQA AEEM PNTT LGCP ATWD GLLC WPTA GSGE WVTL PCPD FFSH FSSE SGAV KRDC TITG WSEP FPPY PVAC PVPL ELLA EEES YFST VK |
| Gene ID: | 2692 |
| Uniprot: | Q02643 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 47kDa |
| Observed MW: | 55kDa |
| Synonyms: | GHRHR, GHRFR, GRFR, IGHD1B |
| Background: | This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. |
| UniProt Protein Function: | GHRHR: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. Defects in GHRHR are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Belongs to the G-protein coupled receptor 2 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Cell development/differentiation; Receptor, GPCR; GPCR, family 2 Chromosomal Location of Human Ortholog: 7p14 Cellular Component: nuclear outer membrane; nuclear matrix; cell surface; cytoplasm; integral to membrane; plasma membrane; nuclear inner membrane; secretory granule Molecular Function:G-protein coupled receptor activity; protein binding; peptide hormone binding; growth factor binding; growth hormone-releasing hormone receptor activity Biological Process: lactation; positive regulation of insulin-like growth factor receptor signaling pathway; response to glucocorticoid stimulus; cell maturation; adenylate cyclase activation; regulation of protein metabolic process; positive regulation of multicellular organism growth; determination of adult life span; reproductive process in a multicellular organism; G-protein signaling, adenylate cyclase activating pathway; response to insulin stimulus; positive regulation of growth hormone secretion; water homeostasis; growth hormone secretion; cAMP-mediated signaling; cellular response to insulin stimulus; response to estrogen stimulus; positive regulation of cell proliferation; positive regulation of cAMP biosynthetic process; somatotropin secreting cell development; hormone metabolic process; regulation of steroid hormone receptor signaling pathway Disease: Isolated Growth Hormone Deficiency, Type Ib |
| NCBI Summary: | This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010] |
| UniProt Code: | Q02643 |
| NCBI GenInfo Identifier: | 3041685 |
| NCBI Gene ID: | 2692 |
| NCBI Accession: | Q02643.2 |
| UniProt Secondary Accession: | Q02643,Q99863, |
| UniProt Related Accession: | Q02643 |
| Molecular Weight: | 47,402 Da |
| NCBI Full Name: | Growth hormone-releasing hormone receptor |
| NCBI Synonym Full Names: | growth hormone releasing hormone receptor |
| NCBI Official Symbol: | GHRHR |
| NCBI Official Synonym Symbols: | GRFR; GHRFR; IGHD1B |
| NCBI Protein Information: | growth hormone-releasing hormone receptor; GRF receptor; GHRH receptor |
| UniProt Protein Name: | Growth hormone-releasing hormone receptor |
| UniProt Synonym Protein Names: | Growth hormone-releasing factor receptor; GRF receptor; GRFR |
| Protein Family: | Growth hormone-releasing hormone receptor |
| UniProt Gene Name: | GHRHR |
| UniProt Entry Name: | GHRHR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GHRHR antibody (CAB8421) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 15s. |
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