Cell Biology Antibodies 8

Anti-GFRA3 Antibody (CAB2955)

(No reviews yet) Write a Review
SKU:
CAB2955
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-GFRA3 Antibody
Antibody SKU:CAB2955
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 32-240 of human GFRA3 (NP_001487.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:A-549, BxPC-3, HepG2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 32-240 of human GFRA3 (NP_001487.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DPLP TESR LMNS CLQA RRKC QADP TCSA AYHH LDSC TSSI STPL PSEE PSVP ADCL EAAQ QLRN SSLI GCMC HRRM KNQV ACLD IYWT VHRA RSLG NYEL DVSP YEDT VTSK PWKM NLSK LNML KPDS DLCL KFAM LCTL NDKC DRLR KAYG EACS GPHC QRHV CLRQ LLTF FEKA AEPH AQGL LLCP CAPN DRGC GERR RNTI APNC A
Gene ID:2676
Uniprot:O60609
Cellular Location:Cell membrane, GPI-anchor, Lipid-anchor
Calculated MW:40kDa/44kDa
Observed MW:45kDa
Synonyms:GFRA3, GDNFR3
Background:The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.
UniProt Protein Function:GFRA3: Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. Belongs to the GDNFR family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 5q31.1-q31.3

Cellular Component: extrinsic to membrane; intracellular membrane-bound organelle; cytoplasm; plasma membrane; external side of plasma membrane

Molecular Function:axon guidance receptor activity; receptor binding

Biological Process: axon guidance; nervous system development; sympathetic nervous system development; neuron migration; signal transduction; peripheral nervous system development

NCBI Summary:The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. [provided by RefSeq, Jul 2008]
UniProt Code:O60609
NCBI GenInfo Identifier:50403696
NCBI Gene ID:2676
NCBI Accession:O60609.2
UniProt Related Accession:O60609
Molecular Weight:Observed Molecular Weight: (Observed)44kD.Predicted Molecular Weight: (Calculated)45kDa.
NCBI Full Name:GDNF family receptor alpha-3
NCBI Synonym Full Names:GDNF family receptor alpha 3
NCBI Official Symbol:GFRA3  
NCBI Official Synonym Symbols:GDNFR3  
NCBI Protein Information:GDNF family receptor alpha-3
UniProt Protein Name:GDNF family receptor alpha-3
Protein Family:GDNF family receptor
UniProt Gene Name:GFRA3  
UniProt Entry Name:GFRA3_HUMAN
Anti-GFRA3 Antibody (CAB2955)Western blot analysis of extracts of various cell lines, using GFRA3 antibody (CAB2955) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
View AllClose

0 Reviews

View AllClose

Related Products