Cell Biology Antibodies 13

Anti-GEMIN5 Antibody (CAB17125)

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SKU:
CAB17125
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GEMIN5 Antibody
Antibody SKU:CAB17125
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 750-950 of human GEMIN5 (NP_056280.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 750-950 of human GEMIN5 (NP_056280.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RTPV KLES IDGN EEES MKEN SGPV ENGV SDQE GEEQ AREP ELPC GLAP AVSR EPVI CTPV SSGF EKSK VTIN NKVI LLKK EPPK EKPE TLIK KRKA RSLL PLST SLDH RSKE ELHQ DCLV LATA KHSR ELNE DVSA DVEE RFHL GLFT DRAT LYRM IDIE GKGH LENG HPEL FHQL MLWK GDLK GVLQ TAAE RGEL TDNL V
Gene ID:25929
Uniprot:Q8TEQ6
Cellular Location:
Calculated MW:168kDa
Observed MW:180kDa
Anti-GEMIN5 Antibody (CAB17125)Western blot - GEMIN5 Rabbit pAb (CAB17125)
Synonyms:GEMIN5, GEMIN-5
Background:This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniProt Protein Function:GEMIN5: the snRNA-binding protein of the SMN complex. The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
UniProt Protein Details:

Protein type:RNA splicing; Nuclear receptor co-regulator; RNA-binding; RNA processing

Chromosomal Location of Human Ortholog: 5q33.2

Cellular Component: nucleoplasm; nuclear body; membrane; cytoplasm; SMN complex; cytosol; nucleus

Molecular Function:protein binding; snRNA binding

Biological Process: nuclear mRNA splicing, via spliceosome; spliceosomal snRNP biogenesis; gene expression; protein complex assembly

NCBI Summary:This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
UniProt Code:Q8TEQ6
NCBI GenInfo Identifier:356461016
NCBI Gene ID:25929
NCBI Accession:NP_001239085.1
UniProt Secondary Accession:Q8TEQ6,Q14CV0, Q8WWV4, Q969W4, Q9H9K3, Q9UFI5,
UniProt Related Accession:Q8TEQ6
Molecular Weight:168,589 Da
NCBI Full Name:gem-associated protein 5 isoform 2
NCBI Synonym Full Names:gem (nuclear organelle) associated protein 5
NCBI Official Symbol:GEMIN5  
NCBI Official Synonym Symbols:GEMIN-5  
NCBI Protein Information:gem-associated protein 5
UniProt Protein Name:Gem-associated protein 5
Protein Family:Gem-associated protein
UniProt Gene Name:GEMIN5  
UniProt Entry Name:GEMI5_HUMAN
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