Anti-Gemin 2 Antibody (CAB19254)
- SKU:
- CAB19254
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- GEMIN2
- Synonyms:
- SIP1
- Synonyms:
- SIP1-delta
- Synonyms:
- gem-associated protein 2
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | Gemin 2 Rabbit mAb |
| Product Code: | CAB19254 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | GEMIN2, SIP1, SIP1-delta, gem-associated protein 2 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human Gemin 2 . |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U2OS, HeLa, MCF7, Mouse testis, Mouse thymus, Rat testis, Rat pancreas |
| Immunogen: | Recombinant protein of human Gemin 2 . |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8487 |
| Uniprot: | O14893 |
| Cellular Location: | Cytoplasm, Nucleus, gem |
| Calculated MW: | 31kDa |
| Observed MW: | 32KDa |
| UniProt Protein Function: | SIP1: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. Belongs to the gemin-2 family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA splicing Chromosomal Location of Human Ortholog: 14q13 Cellular Component: nucleoplasm; spliceosome; cytoplasm; nucleolus; SMN complex; cytosol; nucleus Molecular Function:protein binding Biological Process: RNA splicing, via transesterification reactions; spliceosomal snRNP biogenesis; RNA splicing; spliceosome assembly; gene expression; mRNA processing |
| NCBI Summary: | This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011] |
| UniProt Code: | O14893 |
| NCBI GenInfo Identifier: | 6094289 |
| NCBI Gene ID: | 8487 |
| NCBI Accession: | O14893.1 |
| UniProt Related Accession: | O14893 |
| Molecular Weight: | 31585 |
| NCBI Full Name: | Gem-associated protein 2 |
| NCBI Synonym Full Names: | gem nuclear organelle associated protein 2 |
| NCBI Official Symbol: | GEMIN2 |
| NCBI Official Synonym Symbols: | SIP1; SIP1-delta |
| NCBI Protein Information: | gem-associated protein 2 |
| UniProt Protein Name: | Gem-associated protein 2 |
| UniProt Synonym Protein Names: | Component of gems 2; Survival of motor neuron protein-interacting protein 1; SMN-interacting protein 1 |
| Protein Family: | SNF1 protein kinase |
| UniProt Gene Name: | GEMIN2 |
| UniProt Entry Name: | GEMI2_HUMAN |
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