Anti-Gelsolin Antibody (CAB2612)

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SKU:
CAB2612
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ADF
Synonyms:
AGEL
Research Area:
Cell Biology

Description

Product Name:Gelsolin Rabbit mAb
Product Code:CAB2612
Size:20uL, 50uL, 100uL
Synonyms:ADF, AGEL
Applications:WB, IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Gelsolin
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:C2C12, Mouse lung, HeLa, A-549, RD
Immunogen:A synthesized peptide derived from human Gelsolin
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2934
Uniprot:P06396
Calculated MW:86kDa
Observed MW:86kDa
UniProt Protein Function:Gelsolin: a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Its expression is significantly decreased in many tumors and transformed cell lines. Gelsolin and other proteins including E-cadherin, BRCA, p21WAF, HoxA5, and retinoic acid receptor II are regulated by epigenetic changes in breast cancers. Gelsolin helps mediate the ability of HDAC inhibitors to protect neurons from oxygen/glucose deprivation. Two human isoforms are produced by alternative initiation.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 9q33

Cellular Component: ruffle; focal adhesion; protein complex; perinuclear region of cytoplasm; lamellipodium; extracellular region; cytosol; actin cytoskeleton

Molecular Function:protein binding; calcium ion binding; actin binding

Biological Process: regulation of cell adhesion; actin filament severing; phosphoinositide-mediated signaling; apoptosis; actin nucleation; vesicle-mediated transport; response to ethanol; actin filament polymerization; tissue regeneration; response to folic acid; oligodendrocyte development; barbed-end actin filament capping; cell structure disassembly during apoptosis; aging

Disease: Amyloidosis, Finnish Type

NCBI Summary:The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P06396
NCBI GenInfo Identifier:121116
NCBI Gene ID:2934
NCBI Accession:P06396.1
UniProt Secondary Accession:P06396,Q5T0I2, Q8WVV7, A2A418, A8MUD1, A8MYN7, B7Z373 B7Z5V1, F5H1A8,
UniProt Related Accession:P06396
Molecular Weight:782
NCBI Full Name:Gelsolin
NCBI Synonym Full Names:gelsolin
NCBI Official Symbol:GSN  
NCBI Official Synonym Symbols:ADF; AGEL  
NCBI Protein Information:gelsolin; brevin; actin-depolymerizing factor
UniProt Protein Name:Gelsolin
UniProt Synonym Protein Names:AGEL; Actin-depolymerizing factor; ADF; Brevin
Protein Family:Gelsolin
UniProt Gene Name:GSN  
UniProt Entry Name:GELS_HUMAN
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