Cell Biology Antibodies 10
Anti-GDAP1 Antibody (CAB6601)
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- SKU:
- CAB6601
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GDAP1 Antibody |
| Antibody SKU: | CAB6601 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-225 of human GDAP1 (NP_001035808.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, HepG2, Mouse brain, Mouse spinal cord, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-225 of human GDAP1 (NP_001035808.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MRLN STGE VPVL IHGE NIIC EATQ IIDY LEQT FLDE RTPR LMPD KESM YYPR VQHY RELL DSLP MDAY THGC ILHP ELTV DSMI PAYA TTRI RSQI GNTE SELK KLAE ENPD LQEA YIAK QKRL KSKL LDHD NVKY LKKI LDEL EKVL DQVE TELQ RRNE ETPE EGQQ PWLC GESF TLAD VSLA VTLH RLKF LGFA RRNW GNGK RPNL ETYY ERVL KRKT FNKV L |
| Gene ID: | 54332 |
| Uniprot: | Q8TB36 |
| Cellular Location: | Cytoplasm, Mitochondrion outer membrane, Multi-pass membrane protein |
| Calculated MW: | 33kDa/41kDa |
| Observed MW: | 38kDa |
| Synonyms: | GDAP1, CMT4, CMT4A, CMTRIA |
| Background: | This gene encodes a member of the ganglioside-induced differentiation-associated protein family, which may play a role in a signal transduction pathway during neuronal development. Mutations in this gene have been associated with various forms of Charcot-Marie-Tooth Disease and neuropathy. Two transcript variants encoding different isoforms and a noncoding variant have been identified for this gene. |
| UniProt Protein Function: | GDAP1: the ganglioside-induced differentiation associated protein-1 gene causes autosomal recessive demyelinating or axonal Charcot-Marie-Tooth neuropathy (CMT). |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 8q21.11 Cellular Component: mitochondrion; membrane; cytoplasm; nucleus; integral to mitochondrial outer membrane Biological Process: mitochondrial fission; response to retinoic acid; protein targeting to mitochondrion Disease: Charcot-marie-tooth Disease, Axonal, With Vocal Cord Paresis, Autosomal Recessive; Charcot-marie-tooth Disease, Axonal, Type 2k; Charcot-marie-tooth Disease, Type 4a; Charcot-marie-tooth Disease, Recessive Intermediate A |
| NCBI Summary: | This gene encodes a member of the ganglioside-induced differentiation-associated protein family, which may play a role in a signal transduction pathway during neuronal development. Mutations in this gene have been associated with various forms of Charcot-Marie-Tooth Disease and neuropathy. Two transcript variants encoding different isoforms and a noncoding variant have been identified for this gene. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q8TB36 |
| NCBI GenInfo Identifier: | 269849682 |
| NCBI Gene ID: | 54332 |
| NCBI Accession: | Q8TB36.3 |
| UniProt Secondary Accession: | Q8TB36,A8K957, E7FJF3, E7FJF4, |
| UniProt Related Accession: | Q8TB36 |
| Molecular Weight: | 358 |
| NCBI Full Name: | Ganglioside-induced differentiation-associated protein 1 |
| NCBI Synonym Full Names: | ganglioside induced differentiation associated protein 1 |
| NCBI Official Symbol: | GDAP1 |
| NCBI Official Synonym Symbols: | CMT4; CMT4A; CMTRIA |
| NCBI Protein Information: | ganglioside-induced differentiation-associated protein 1; Charcot-Marie-Tooth neuropathy 4A; ganglioside differentiation associated protein 1 |
| UniProt Protein Name: | Ganglioside-induced differentiation-associated protein 1 |
| Protein Family: | Ganglioside-induced differentiation-associated protein |
| UniProt Gene Name: | GDAP1 |
| UniProt Entry Name: | GDAP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GDAP1 antibody (CAB6601) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using GDAP1 antibody (CAB6601) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat heart using GDAP1 antibody (CAB6601) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using GDAP1 antibody (CAB6601) at dilution of 1:100 (40x lens). |
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