Cell Biology Antibodies 16

Anti-GCGR Antibody (CAB10617)

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SKU:
CAB10617
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GCGR Antibody
Antibody SKU:CAB10617
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human GCGR (NP_000151.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human GCGR (NP_000151.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPPC QPQR PLLL LLLL LACQ PQVP SAQV MDFL FEKW KLYG DQCH HNLS LLPP PTEL VCNR TFDK YSCW PDTP ANTT ANIS CPWY LPWH HKVQ HRFV FKRC GPDG QWVR GPRG QPWR DASQ CQMD GEEI EVQK EVAK MYSS
Gene ID:2642
Uniprot:P47871
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:54kDa
Observed MW:Refer to figures
Synonyms:GCGR, GGR, GL-R
Background:The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).
UniProt Protein Function:GCGR: This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function:glucagon receptor activity; guanyl-nucleotide exchange factor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; generation of precursor metabolites and energy; glucose homeostasis; regulation of blood pressure; response to nutrient; response to starvation

Disease: Diabetes Mellitus, Noninsulin-dependent

NCBI Summary:The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
UniProt Code:P47871
NCBI GenInfo Identifier:1346144
NCBI Gene ID:2642
NCBI Accession:P47871.1
UniProt Secondary Accession:P47871,Q2M3M5,
UniProt Related Accession:P47871
Molecular Weight:54,009 Da
NCBI Full Name:Glucagon receptor
NCBI Synonym Full Names:glucagon receptor
NCBI Official Symbol:GCGR  
NCBI Official Synonym Symbols:GGR; GL-R  
NCBI Protein Information:glucagon receptor
UniProt Protein Name:Glucagon receptor
Protein Family:Glucagon receptor
UniProt Gene Name:GCGR  
UniProt Entry Name:GLR_HUMAN
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