Epigenetics & Nuclear Signaling Antibodies 1
Anti-GATA1 Antibody (CAB0475)
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- SKU:
- CAB0475
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-GATA1 Antibody |
| Antibody SKU: | CAB0475 |
| Antibody Size: | 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human GATA1 |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NIH/3T3 |
| Immunogen: | A synthetic peptide of human GATA1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2623 |
| Uniprot: | P15976 |
| Cellular Location: | Nucleus |
| Calculated MW: | 34kDa/35kDa/42kDa |
| Observed MW: | 50kDa |
| Synonyms: | GATA1, ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT |
| Background: | This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. |
| UniProt Protein Function: | Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). |
| NCBI Summary: | This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P15976 |
| NCBI GenInfo Identifier: | 120956 |
| NCBI Gene ID: | 2623 |
| NCBI Accession: | P15976.1 |
| UniProt Secondary Accession: | P15976,Q96GB8, |
| UniProt Related Accession: | P15976 |
| Molecular Weight: | 34,232 Da |
| NCBI Full Name: | Erythroid transcription factor |
| NCBI Synonym Full Names: | GATA binding protein 1 |
| NCBI Official Symbol: | GATA1 |
| NCBI Official Synonym Symbols: | GF1; GF-1; NFE1; XLTT; ERYF1; NF-E1; XLANP; XLTDA; GATA-1 |
| NCBI Protein Information: | erythroid transcription factor |
| UniProt Protein Name: | Erythroid transcription factor |
| UniProt Synonym Protein Names: | Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein |
| Protein Family: | GATA transcription factor |
| UniProt Gene Name: | GATA1 |
 | Western blot analysis of extracts of NIH/3T3 cells, using GATA1 antibody (CAB0475). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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