Developmental Biology
Anti-GAS7 Antibody (CAB14179)
- SKU:
- CAB14179
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-GAS7 Antibody |
| Antibody SKU: | CAB14179 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-412 of human GAS7 (NP_001124303.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, A375, Mouse brain, Mouse testis, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-412 of human GAS7 (NP_001124303.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVPP PPGE ESQT VILP PGWQ SYLS PQGR RYYV NTTT NETT WERP SSSP GIPA SPGS HRSS LPPT VNGY HASG TPAH PPET AHMS VRKS TGDS QNLG SSSP SKKQ SKEN TITI NCVT FPHP DTMP EQQL LKPT EWSY CDYF WADK KDPQ GNGT VAGF ELLL QKQL KGKQ MQKE MSEF IRER IKIE EDYA KNLA KLSQ NSLA SQEE GSLG EAWA QVKK SLAD EAEV HLKF SAKL HSEV EKPL MNFR ENFK KDMK KCDH HIAD LRKQ LASR YASV EKAR KALT ERQR DLEM KTQQ LEIK LSNK TEED IKKA RRKS TQAG DDLM RCVD LYNQ AQSK WFEE MVTT TLEL ERLE VERV EMIR QHLC QYTQ LRHE TDMF NQST VEPV DQLL RKVD PAKD RELW VREH KTGN IRPV DMEI |
| Gene ID: | 8522 |
| Uniprot: | O60861 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 39kDa/47kDa/54kDa |
| Observed MW: | 54kDa |
| Synonyms: | GAS7, MLL/GAS7 |
| Background: | Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. |
| UniProt Protein Function: | GAS7: May play a role in promoting maturation and morphological differentiation of cerebellar neurons. A chromosomal aberration involving GAS7 is found in acute myeloid leukemia. Translocation t(11;17)(q23;p13) with MLL/HRX. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Actin-binding; Transcription factor; Oncoprotein Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: ruffle; cytoplasm; actin filament Molecular Function:actin filament binding; transcription factor activity Biological Process: regulation of cell shape; actin filament bundle formation; regulation of transcription, DNA-dependent; actin filament polymerization; cell cycle arrest; neurite morphogenesis |
| NCBI Summary: | Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60861 |
| NCBI GenInfo Identifier: | 218512092 |
| NCBI Gene ID: | 8522 |
| NCBI Accession: | O60861.3 |
| UniProt Related Accession: | O60861 |
| Molecular Weight: | Observed: 50 kDaPredicted: 55 kDa |
| NCBI Full Name: | Growth arrest-specific protein 7 |
| NCBI Synonym Full Names: | growth arrest specific 7 |
| NCBI Official Symbol: | GAS7 |
| NCBI Protein Information: | growth arrest-specific protein 7 |
| UniProt Protein Name: | Growth arrest-specific protein 7 |
| Protein Family: | Growth arrest-specific protein |
| UniProt Gene Name: | GAS7 |
| UniProt Entry Name: | GAS7_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GAS7 antibody (CAB14179) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Western blot analysis of extracts of various cell lines, using GAS7 antibody (CAB14179) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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