| UniProt Protein Function: | GAP43: This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. Belongs to the neuromodulin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell surface Chromosomal Location of Human Ortholog: 3q13.31 Cellular Component: axon; cell junction; cytoplasm; filopodium membrane; plasma membrane; postsynaptic density Molecular Function:calmodulin binding; phosphatidylserine binding; protein binding Biological Process: axon choice point recognition; cell fate commitment; glial cell differentiation; protein kinase C activation; regulation of filopodium formation; regulation of growth; response to wounding; tissue regeneration |
| NCBI Summary: | The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P17677 |
| NCBI GenInfo Identifier: | 128100 |
| NCBI Gene ID: | 2596 |
| NCBI Accession: | P17677.1 |
| UniProt Secondary Accession: | P17677,A8K0Y4, |
| UniProt Related Accession: | P17677 |
| Molecular Weight: | |
| NCBI Full Name: | Neuromodulin |
| NCBI Synonym Full Names: | growth associated protein 43 |
| NCBI Official Symbol: | GAP43 |
| NCBI Official Synonym Symbols: | B-50; PP46 |
| NCBI Protein Information: | neuromodulin |
| UniProt Protein Name: | Neuromodulin |
| UniProt Synonym Protein Names: | Axonal membrane protein GAP-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46 |
| Protein Family: | Neuromodulin |
| UniProt Gene Name: | GAP43 |
| UniProt Entry Name: | NEUM_HUMAN |
