UniProt Protein Function: | GABRR2: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR2 sub-subfamily. 2 isoforms of the human protein are produced by alternative initiation. |
UniProt Protein Details: | Protein type:Transporter, ion channel; Membrane protein, integral; Membrane protein, multi-pass; Transporter Chromosomal Location of Human Ortholog: 6q15 Cellular Component: integral to plasma membrane; plasma membrane Biological Process: signal transduction; synaptic transmission; transport |
NCBI Summary: | Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA type A receptor complex. This gene exists on chromosome 6q next to the gene encoding the rho 1 subunit of the GABA type A receptor, in a region thought to be associated with susceptibility for psychiatric disorders and epilepsy. Polymorphisms in this gene may also be associated with alcohol dependence, and general cognitive ability. [provided by RefSeq, Apr 2016] |
UniProt Code: | P28476 |
NCBI GenInfo Identifier: | 410516956 |
NCBI Gene ID: | 2570 |
NCBI Accession: | P28476.5 |
UniProt Secondary Accession: | P28476,Q9H153, A2BDE4, |
UniProt Related Accession: | P28476 |
Molecular Weight: | 56,817 Da |
NCBI Full Name: | Gamma-aminobutyric acid receptor subunit rho-2 |
NCBI Synonym Full Names: | gamma-aminobutyric acid type A receptor rho2 subunit |
NCBI Official Symbol: | GABRR2 |
NCBI Protein Information: | gamma-aminobutyric acid receptor subunit rho-2 |
UniProt Protein Name: | Gamma-aminobutyric acid receptor subunit rho-2 |
UniProt Synonym Protein Names: | GABA(A) receptor subunit rho-2; GABA(C) receptor |
Protein Family: | Gamma-aminobutyric acid receptor |
UniProt Gene Name: | GABRR2 |
UniProt Entry Name: | GBRR2_HUMAN |