Signal Transduction Antibodies 1
Anti-GABRR2 Antibody (CAB10111)
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- SKU:
- CAB10111
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-GABRR2 Antibody |
| Antibody SKU: | CAB10111 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-450 of human GABRR2 (NP_002034.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HL-60, HepG2, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-450 of human GABRR2 (NP_002034.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TVQE RKER KLRE KFPC MCGM LHSK TMML DGSY SESE ANSL AGYP RSHI LTEE ERQD KIVV HLGL SGEA NAAR KKGL LKGQ TGFR IFQN THAI DKYS RLIF P |
| Gene ID: | 2570 |
| Uniprot: | P28476 |
| Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| Calculated MW: | 54kDa/56kDa |
| Observed MW: | 65kDa |
| Synonyms: | GABRR2 |
| Background: | Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA type A receptor complex. This gene exists on chromosome 6q next to the gene encoding the rho 1 subunit of the GABA type A receptor, in a region thought to be associated with susceptibility for psychiatric disorders and epilepsy. Polymorphisms in this gene may also be associated with alcohol dependence, and general cognitive ability. |
| UniProt Protein Function: | GABRR2: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR2 sub-subfamily. 2 isoforms of the human protein are produced by alternative initiation. |
| UniProt Protein Details: | Protein type:Transporter, ion channel; Membrane protein, integral; Membrane protein, multi-pass; Transporter Chromosomal Location of Human Ortholog: 6q15 Cellular Component: integral to plasma membrane; plasma membrane Biological Process: signal transduction; synaptic transmission; transport |
| NCBI Summary: | Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA type A receptor complex. This gene exists on chromosome 6q next to the gene encoding the rho 1 subunit of the GABA type A receptor, in a region thought to be associated with susceptibility for psychiatric disorders and epilepsy. Polymorphisms in this gene may also be associated with alcohol dependence, and general cognitive ability. [provided by RefSeq, Apr 2016] |
| UniProt Code: | P28476 |
| NCBI GenInfo Identifier: | 410516956 |
| NCBI Gene ID: | 2570 |
| NCBI Accession: | P28476.5 |
| UniProt Secondary Accession: | P28476,Q9H153, A2BDE4, |
| UniProt Related Accession: | P28476 |
| Molecular Weight: | 56,817 Da |
| NCBI Full Name: | Gamma-aminobutyric acid receptor subunit rho-2 |
| NCBI Synonym Full Names: | gamma-aminobutyric acid type A receptor rho2 subunit |
| NCBI Official Symbol: | GABRR2 |
| NCBI Protein Information: | gamma-aminobutyric acid receptor subunit rho-2 |
| UniProt Protein Name: | Gamma-aminobutyric acid receptor subunit rho-2 |
| UniProt Synonym Protein Names: | GABA(A) receptor subunit rho-2; GABA(C) receptor |
| Protein Family: | Gamma-aminobutyric acid receptor |
| UniProt Gene Name: | GABRR2 |
| UniProt Entry Name: | GBRR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GABRR2 antibody (CAB10111) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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