Signal Transduction Antibodies 1

Anti-GABRQ Antibody (CAB13226)

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SKU:
CAB13226
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-GABRQ Antibody
Antibody SKU:CAB13226
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-600 of human GABRQ (NP_061028.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:Jurkat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-600 of human GABRQ (NP_061028.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NYLF YSRG PRRQ PRRH RRPR RVIA RYRY QQVV VGNV QDGL INVE DGVS SLPI TPAQ APLA SPES LGSL TSTS EQAQ LATS ESLS PLTS LSGQ APLA TGES LSDL PSTS EQAR HSYG VRFN GFQA DDSI IPTE IRNR VEAH GHGV THDH EDSN ESLS SDER HGHG PSGK PMLH HGEK GVQE AGWD LDDN NDKS DCLA IKEQ FKCD TNST WGLN DDEL MAHG QEKD SSSE SEDS CPPS PGCS FTEG FSFD LFN
Gene ID:55879
Uniprot:Q9UN88
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Calculated MW:72kDa
Observed MW:72kDa
Synonyms:GABRQ, THETA
Background:The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. This gene location is also the candidate region of two different neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3).
UniProt Protein Function:GABRQ: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRQ sub-subfamily.
UniProt Protein Details:

Protein type:Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function:GABA-A receptor activity; neurotransmitter transporter activity; transmembrane receptor activity

Biological Process: signal transduction

NCBI Summary:The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. This gene location is also the candidate region of two different neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3). [provided by RefSeq, Nov 2009]
UniProt Code:Q9UN88
NCBI GenInfo Identifier:13959382
NCBI Gene ID:55879
NCBI Accession:Q9UN88.2
UniProt Secondary Accession:Q9UN88,Q32MB4, Q9NZK8, A6NFN1,
UniProt Related Accession:Q9UN88
Molecular Weight:72,022 Da
NCBI Full Name:Gamma-aminobutyric acid receptor subunit theta
NCBI Synonym Full Names:gamma-aminobutyric acid type A receptor theta subunit
NCBI Official Symbol:GABRQ  
NCBI Official Synonym Symbols:THETA  
NCBI Protein Information:gamma-aminobutyric acid receptor subunit theta
UniProt Protein Name:Gamma-aminobutyric acid receptor subunit theta
UniProt Synonym Protein Names:GABA(A) receptor subunit theta
Protein Family:Gamma-aminobutyric acid receptor
UniProt Gene Name:GABRQ  
UniProt Entry Name:GBRT_HUMAN
Anti-GABRQ Antibody (CAB13226)Western blot analysis of extracts of Jurkat cells, using GABRQ antibody (CAB13226) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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