Signal Transduction Antibodies 1
Anti-GABRE Antibody (CAB14239)
(No reviews yet)
Write a Review
- SKU:
- CAB14239
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-GABRE Antibody |
| Antibody SKU: | CAB14239 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-253 of human GABRE (NP_004952.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | SH-SY5Y |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-253 of human GABRE (NP_004952.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PQTE SKNE ASSR DVVY GPQP QPLE NQLL SEET KSTE TETG SRVG KLPE ASRI LNTI LSNY DHKL RPGI GEKP TVVT VEIS VNSL GPLS ILDM EYTI DIIF SQTW YDER LCYN DTFE SLVL NGNV VSQL WIPD TFFR NSKR THEH EITM PNQM VRIY KDGK VLYT IRMT IDAG CSLH MLRF PMDS HSCP LSFS SFSY PENE MIYK WENF KLEI NEKN SWKL FQFD FTGV SNK |
| Gene ID: | 2564 |
| Uniprot: | P78334 |
| Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| Calculated MW: | 41kDa/57kDa |
| Observed MW: | 58kDa |
| Synonyms: | GABRE |
| Background: | The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. |
| UniProt Protein Function: | GABRE: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRE sub-subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: Xq28 Cellular Component: integral to plasma membrane Biological Process: gamma-aminobutyric acid signaling pathway; transport |
| NCBI Summary: | The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008] |
| UniProt Code: | P78334 |
| NCBI GenInfo Identifier: | 13124728 |
| NCBI Gene ID: | 2564 |
| NCBI Accession: | P78334.2 |
| UniProt Secondary Accession: | P78334,O15345, O15346, Q6PCD2, Q99520, E7ET93, |
| UniProt Related Accession: | P78334 |
| Molecular Weight: | 41,760 Da |
| NCBI Full Name: | Gamma-aminobutyric acid receptor subunit epsilon |
| NCBI Synonym Full Names: | gamma-aminobutyric acid type A receptor epsilon subunit |
| NCBI Official Symbol: | GABRE |
| NCBI Protein Information: | gamma-aminobutyric acid receptor subunit epsilon |
| UniProt Protein Name: | Gamma-aminobutyric acid receptor subunit epsilon |
| UniProt Synonym Protein Names: | GABA(A) receptor subunit epsilon |
| Protein Family: | Gamma-aminobutyric acid receptor |
| UniProt Gene Name: | GABRE |
| UniProt Entry Name: | GBRE_HUMAN |
 | Western blot analysis of extracts of SH-SY5Y cells, using GABRE antibody (CAB14239) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
View AllClose
Related Products
