Signal Transduction Antibodies 1

Anti-GABRB3 Antibody (CAB10015)

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SKU:
CAB10015
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-GABRB3 Antibody
Antibody SKU:CAB10015
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 330-460 of human GABRB3 (NP_000805.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human
Positive Samples:SH-SY5Y, A-549, BT-474
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 330-460 of human GABRB3 (NP_000805.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IFFG RGPQ RQKK LAEK TAKA KNDR SKSE SNRV DAHG NILL TSLE VHNE MNEV SGGI GDTR NSAI SFDN SGIQ YRKQ SMPR EGHG RFLG DRSL PHKK THLR RRSS QLKI KIPD LTDV NAID RWSR IVFP FTF
Gene ID:2562
Uniprot:P28472
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Calculated MW:45kDa/46kDa/54kDa
Observed MW:65kDa
Synonyms:GABRB3, ECA5, EIEE43
Background:This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described.
UniProt Protein Function:Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
NCBI Summary:This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]
UniProt Code:P28472
NCBI GenInfo Identifier:4503867
NCBI Gene ID:2562
NCBI Accession:NP_000805.1
UniProt Secondary Accession:P28472,Q14352, Q96FM5, B7Z2W1, B7Z825, F5H3D2, H7BYV8
UniProt Related Accession:P28472
Molecular Weight:54,379 Da
NCBI Full Name:gamma-aminobutyric acid receptor subunit beta-3 isoform 1
NCBI Synonym Full Names:gamma-aminobutyric acid type A receptor beta3 subunit
NCBI Official Symbol:GABRB3  
NCBI Official Synonym Symbols:ECA5; EIEE43  
NCBI Protein Information:gamma-aminobutyric acid receptor subunit beta-3
UniProt Protein Name:Gamma-aminobutyric acid receptor subunit beta-3
UniProt Synonym Protein Names:GABA(A) receptor subunit beta-3
Protein Family:Gamma-aminobutyric acid receptor
UniProt Gene Name:GABRB3  
Anti-GABRB3 Antibody (CAB10015)Western blot analysis of extracts of various cell lines, using GABRB3 antibody (CAB10015) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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